Objective
The observation of the expression of S-100β protein and NSE during the process of bilateral middle carotid stenosis rabbits’ ischemic brain damage and the discussion of the effects propofol to ischemic brain damage caused by low blood pressure, provide the theory basis for the application of propofol in Clinical anesthesia.
MethodsAny male and female Eighteen healthy adult rabbits with the weight of 2.2-2.4 kg which were purchased from the Experimental Animal Center of Shanxi Medical University, were divided into three groups randomly, one group with six. Physiological saline compare group (NS group): injected with saline only,without Lowering blood pressure; lower blood pressure with bloodletting group (B group): bloodletting the modeling rabbit to low the blood pressure30%and maintain ten minutes;
propofol group (Pr group):
inject the propofol with intravenous injection pump as20mg/kg per hour to low the blood pressure30%and maintain ten minutes. Collect the blood samples and brain tissue within seven hours after lowering the blood pressure.ResultsCompared with the Physiological saline compare group(NS group), the expression of S-100β protein and NSE of lower blood pressure with bloodletting group (B group)and propofol group (Pr group) are risen, as well as the cell apoptosis index.
Compared with the lower blood pressure with bloodletting group (B group), the expression of S-100β protein and NSE of propofol group (Pr group)are lowered.,as well as the cell apoptosis index.
Conclusion
The blood pressure low caused by bloodletting results in carotid artery stenosis rabbits’ ischemic brain damage, while the blood pressure low caused by propofol does not result in carotid artery stenosis rabbits’ischemic brain damage. This shows that propofol has protective effect for ischemic brain damage.