Purpose: To study and evaluate the effect of subconjunctival injection of bevacizumab on experimental corneal neovascularization in rats induced by corneal suture and the expression of corenal vascular endothelial growth factor.Methods: The rat model of corneal neovascularization(CNV) was induced by corneal suture. Seventy two wistar rats were randomly divided into experimental group and control group, [...]
Objective:In the experiment, we established the rabbit models of mandibular fractures and glued by fibrin glue(FG), and then detected the expression of VEGF in osteotylus by real-time PCR and to observe ossification during the process of fracture healing. To studies it’s mechanism for promoting fracture healing and possibility which applies in the fracture of jaw [...]
ObjectiveWe explore the mechanism of the restriction of recurrence of endometriosis (EMs) using the herbal medicine of HuoXueXiaoYi through observing the changes of the ectopic endometrium volume, the pathologic, and the expression levels of ICAM-1,MMP-9,VEGF.MethodsGroup:Seventy SD female rats were randomly divided into seven groups and every group has ten rats. There are one normal control [...]
OBJECTIVE: To detect the expression of VEGF and Ang-2 in rectal carcinoma tissues, rectal adenoma tissues and normal tissues , investigate its relationship with clinicopathlolgic factors and mcrovessel density (MVD) in tumor tissue.METHODS: VEGF, Ang-2 and factorⅧrelated antigen were stained immunohistochemically in 60 cases of primary rectal cancer, 30 cases of rectal adenoma and 10cases [...]
Objective:To observe the expressional changes of angiopoietin-2 (Ang-2), pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in human umbilical vein endothelial cells (HUVECs) cultured with high glucose, and i nvestigate the effects of angiopoietin-1 (Ang-1) on these factors in high glucose.Methods:The HUVECs were divided into the following groups:normal group (5.5 mmol/L glucose), mannitol [...]
Objective:To investigate the anti-tumor effect of Rhaponticum uniflorum water extract (RUWE) in H22-bearing mice research and its mechanisms.Methods:The H22 transplanted mouse models were established and randomly divided into 5 groups:model, high, medium and low dose RUWE, and 5-Fu group. Animals were treated with RUWE for 10 days, then the tumor growth inhibition ratios, spleen and [...]
Objects:To investigate the anti-atherosclerosis effects and mechanism of Candesartan on experimental atherosclerosis rats.Methods:Male SD rats of ten-months were randomly divided into 5 groups:A(normal rats),B(atherosclerosis rats),C(atherosclerosis rats fed with candesartan 1 mg.kg-1.d-1), D(atherosclerosis rats fed with candesartan 5 mg.kg-1.d-1) and E(atherosclerosis rats fed with candesartan 10mg.kg-1.d-1). The rats of group B,C,D,E were fed with high lipid [...]
Objective:1.Through analyzing the relationship between VEGF, P53 gene expression level in peripheral blood and syndrome differentiation in colorectal cancer,to provide some ideas for curing the colorectal cancer with the combination of chinese medicine and western medicine, and look for the junction of traditional chinese medicine and western medicine from molecular biology angle;2.To analyze the changes [...]
Sea cucumber, an important food and medicine resource, has lots of bioactive substances, such as sea cucumber polysaccharide, saponins, collagen proteins and cerebrosides. The sea cucumber polysaccharide is one of the most important bioactive substance, and weight about 7%-10% of the body wall of the sea cucumber. There are sea cucumber chondroitin sulfate (SC-CHS) and [...]
Objective:To review the effect of the anti-tumor and immune function on tumor-bearing mice, through research antineoplasmic activity of PAMD (phenolicalkaloids of Menispermum dauricum) in internal experiment; and through test mRNA expression of cyclooxygenase 2 and vascular endothelial growth factor in tissue of tumor,to approach the themechanism of action about the possible anti-tumor growth and development.Methods:The [...]
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