Objective:The aquaporins (AQPs) are a familyof small integral plasma membrane proteins that transport water and small molecules such as glycerol, urea, and even ions inspecial cases, across the plasma membrane. They are conserved in bacteria,plants, and animals. To date,13members of the AQP family have been identified in mammals. The nasal mucosa vascular endothelial growth factor [...]
Background:The liver is a complex digestive organ in our body, which has a strong regenerative capacity. Liver regeneration after partial hepatectomy that is dependent on the regenerative capacity of the residual liver tissue. Recently, the mechanism of liver regeneration after injury which regulated by traditional Chinese medicine has become a hot spot. This experiment was [...]
Background: Ischemic heart disease is a serious cardiovascular disease, itthreatens human health, and the pathogenesis is closely linked with complex andmultiple systems. In cellular and molecular levels, ischemia and hypoxia could affectthe energy metabolism, metabolism, and even gene expressions of myocardial cells，all these changes simultaneously contribute to the development process of myocardialischemic disease. Traditional Chinese [...]
Objective: The aim of this study was to investigate the mechanism of lenalidomideon the growth of human hepatoma cell line SMMC-7721cells in vitro growth and tocompare of curative effect with thalidomide.Methods: SMMC-7721cells were treated with lenalidomide or thalidomide atdifferent concentrations. CCK-8assay was used to assesse the cell growth inhibition andcompare the differences between them for [...]
Objective:To evaluate the therapeutic effect of green tea polyphenols in corneal alkali burn in mice through the establishment of the mouse corneal alkali burn models.Methods:Forty healthy C57/BL male mice were randomly divided into two groups (twenty mice in each group):the control group and GTP group.To establish corneal alkali burn models, left eyes of the mice [...]
Objective:To investigate the expression of PTTG、VEGF、p53、TSP-1。MVD (evaluated by CD34) in Colorectal carcinoma and to explore the relationship beteween PTTG、VEGF、p53、 TSP-1and MVD and clinical parametersMethods:Using immunohistochemical En Vision staining method,the expression of PTTG,VEGF,p53,TSP-1and MVD were detected in18normal tissue,20colorectal adenoma,44colorectal adenocarcinoma, and the statistic method was used to analyze the expression of PTTG correlated with the expression [...]
Objective:1.The imaging features in two types of oligodendrogliomas were explored for better clinical differential diagnosis and treatment guidance.2. The positive rate of expression VEGF and CD44v6in different levels of Oligodendrogliomas were discussed, in order to understand this tumors from microcosmic.3.Imaging features, expression and Significance of VEGF and CD44v6in oligodendrogliomas, from the perspectivity of molecular biology [...]
Aim:To observe the effect of salvianolic acid B (Sal B) on proliferation, migration and tube formation in vitro, to explore the protective effects of Sal B of myocardial angiogenesis and molecular mechanism rats with acute myocardial ischemia; to investigate the vasodilatory effect of Sal B and its mechanisms.Methods:1(1) MTT method was used to determine the [...]
Objective:To investigate the effects of the ethanol extract of yanhusuo and the alkaloid fraction of yanhusuo on anti-angiogenesis in vivo and the regulation of VEGF.Methods:1. MTT assay was used to observe the effects of ethanol extract of yanhusuo and the alkaloid fraction of yanhusuo on the proliferation of human gastric cancer cell lines BGC-823, human [...]
Objective To investigate the expression and significance of CXCR4and VEGF,as well as their correlations in Nephroblastoma and to explore the clinical signifivance.Methods The expression of CXCR4and VEGF in10cases of normal kidney tissue and30samples of Nephroblastoma tissue selected with complete clinicopathological data were studied by SABC immunohistochemistry.Results The expression rate of CXCR4and VEGF in normal kidney [...]
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