AIDS stands for Acquired Immunodeficiency Syndrome, it is caused by HIV(HumanImmunodeficiency Virus).This disease is very contagious and has high fatality rate. Morethan2million people died of AIDS each year. The HIV virus poses one of the biggest viralthreats to human today.HIV DNA vaccine is considered one of the noval ways that we canused to delvelop potential [...]
Objective:To develop the rational DLL4cDNA vaccine to renal cell carcinoma and the mechanism of the vaccine on nude mice RCC models, we have thus developed the study to explore the possible immunization by DLL4-encoding plasmid DNA vaccine to evaluate the vaccine efficacy by some nude mice admitted to the RCC. We investigated the tumor local [...]
The development of an effective anti-HIV-1vaccine has been hampered by high mutation rates of the viral envelop, either within or outside of the epitope, among many other reasons. Using an innovative immunogen design, we generated a15-mer peptide that prominently expresses the triplet sequence GPG and induced high titer serum antibodies in mice and rabbits against [...]
There have been quite substantial declines in cervical cancer morbidity and mortality, However, cervical cancer still remains to be the second common female cancer, which added great concerns on women’s health and financial burden. With the establishment of the role of high-risk types of HPV in the etiology of the majority of cervical cancers, the [...]
Objective:Lung cancer, one of the most popular malignant tumors, has become a world-wide treat to the health of human being. As well-known, radiation and chemotherapy-induced cell death(including apoptosis and necrosis) is currently a very important means to clear cancer. In recent years, with the development of Immunology, research has shown that dealing with tumor cells [...]
Objective:Lung cancer, one of the most popular malignant tumors, has become a world-wide treat to the health of human being. As well-known, radiation and chemotherapy-induced cell death(including apoptosis and necrosis) is currently a very important means to clear cancer. In recent years, with the development of Immunology, research has shown that dealing with tumor cells [...]
Objective: Group A streptococcus (GAS) is the most common bacterial pathogen of Gram-positive bacteria which can cause serious invasive infection, empoison diseases and autoimmunity diseases. By epidemiology discover in 5 citys of China, there are 50%, even 70%~ 80% in countrysides, of children ages in 8~13 infected [1].In all diseases caused by GAS, the most [...]
Objectives:Outer membrane vesicles from the strain 29325 of Nm serogroup B was extracted with three different methods, the toxicity and immunogenicity of the resulting OMV vaccines was compared, with the objective to select the best approch for vaccine development. Methods:The OMV vaccines were harvested by ultracentrifuged, Protein content was determined by Lowery assay and LOS [...]
Objectives:Outer membrane vesicles from the strain 29325 of Nm serogroup B was extracted with three different methods, the toxicity and immunogenicity of the resulting OMV vaccines was compared, with the objective to select the best approch for vaccine development. Methods:The OMV vaccines were harvested by ultracentrifuged, Protein content was determined by Lowery assay and LOS [...]
In this paper, two transmission models of malaria under a new way of vaccination are formulated and analyzed. We consider two kinds of models. For the model with standard incidence, explicit expressions of the basic reproduction number R0(ψ) and the effective reproduction number R(ψ) are obtained, where R0(ψ)<R(ψ).It is shown that the disease-free equilibrium is [...]
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