Periodontitis is a common and chronic inflammatory oral disease caused by bacteria leading to destruction of tissues supporting the teeth. Besides that, the toxins produced by these bacteria and their antigens, inducing the periodontal tissue cells to produce cytokines, increases periodontal Inflammation.as periodontitis’s relation pathogens, actinomyces naeslundii can induce a large amount of tumor necrosis [...]
Objective:The study was to explore the effect and the possible mechanism of PNS treating pulmonary contusion induced by heavy free-fallers on rabbits by measuring tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β) and malondialdehyde (MDA), combined with wet to dry proportion and pathological changes of lung tissues, providing the experimental and theoretical evidence for the clinical using of PNS.Methods:24 [...]
Effects of Kadsura Pepper Stem Extract on β-amyloid Protein-induced Activation of Microglia in Vitro
Alzheimer’s disease is a progressive brain neurodegenerative disorder. The deposition of (3-amyloid protein causes the activition of microglia and releasing of inflammatory factors that induces the chronic inflammatory reaction, which may be the most important pathological mechanism of Alzheimer’s disease pathogenesis. Rescarchs indicate thatβ-amyloid protein can activate microglia and express inflammatory factors (IL-1β, IL-6, TNF-α, [...]
Objective:To explore the clinical value of transcutaneous acupoint electrical stimulation (TAES) combined with general intravenous anesthesia in endoscopic thyroidectomy.Methods:60 patients (ASAⅠ-Ⅱ)undergoing endoscopic thyroidectomy were randomly divided into 2 groups with 30 patients in each group.Treatment groups:TAES combined with general intravenous anesthesia and control group: total intravenous anesthesia.Before induction of anesthesia, treatment group was stimulated at [...]
Objective:to detect serum tumor necrosis factor-a (TNF-a), interleukin-18 (IL-18), Adiponectin (ADPN) and fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), Urinary albumin excretion rates (UAER) and other indicators in Patients with type 2 diabetic nephropathy. Explore type 2 diabetes nephrosis patient serum TNF-a, IL-18, ADPN level of change and its affecting factors and the relationship between [...]
Objective:To observe the protective effect of curcumin against ActD/TNF-α-induced synergistically apoptosis in PC12 cells, and explore the mechanism, contributing a new experimental support to the application of curcumin in the prevention and treatment of HIV-associated neurocognitive disorders (HAND) and related diseases.Methods:1. Culture PC12 cells in the DMEM high glucose medium that containing 5% fetal bovine [...]
Objective:To investigate the effect of grape seed procyanidins (GSP) on the blood pressure in renovascular hypertensive (RH) rats and its mechanism.Methods:2K1C method was used to establish the RH rat models. Meanwhile,8 rats were served as controls. After 2 weeks of operation,32 rats which tail systolic pressure increased above 130 mmHg were selected as successful RH [...]
Astragalus Polydsaccharide(APS) is one of the most effective and important ingredient isolated from the roots of Astragalus membranaceus, which signifycantly enhances immunity organ’s function, promotes production of antibodies, improves macrophage activity, and strengthens of T,B cells and other immune cells such as NK cells.Lipopolysaccharide is a large molecular structure ingredient in the outer membrane of [...]
Objective: The present study was undertaken to investigate the effect of brain oxidative stress on the pathogenesis of angina. The NADPH oxidase inhibitor APO decreases the levels of oxidative stress in the paraventricular nucleus and improves cardiac function in angina rats.Methods and Results: Adult male Sprage-Dawley rats underwent left anterior descending coronary artery ligation to [...]
Obj ective:By observing Suanzaorentang rat model of depression in TNF-α, IL-1B, c-fos expression and explore its mechanism of prevention and treatment of depression.Methods:The experimental method of reproduction by chronic stress rat model of depression, the election body weight, behavior similar to scores of female Wistar rats of clean grade 72, were randomly divided into 6 [...]
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