Cerebrovascular disease is the clinical common disease. Fifty-seventy percent of urvival patients has left over different levels of disabilities, which have serious impact on the health and survival quality of the patients. In addition, with the development of the medical technology, the risk of the injury after brain ischemia/reperfusion during the perioperative period also has [...]
Objective:The aims of this article are to observe the effects of tetramethylpyrazine (TMP) on the neuronal apoptosis in the superficial dorsal horn caused by chronic constrictive injury of sciatic nerve and the expressions of caspase-3and bcl-2which are the two genes closely related with apoptosis, and to explore the therapeutic effects and potential mechanism of tetramethylpyrazine [...]
Objective: The exact effext of tetramethylpyrazine against myocardial ischemia,relaxing blood vessels, inhibiting platelet body gathered outside the protective effect oncoronary endothelial vascular endothelial cell injury. The tetramethylpyrazine has shortelimination half-life in vivo, the oral need a day multiple dose and oral administration of aserious first-pass effect, bioavailability of TMP is only10-30%. Transdermal therapeuticsystem (TTS) system [...]
Researching the mechanism and treatment for injury of brain ischemia-reperfusion, is hot-spot in life science research for years, having important medical value. Moreover, According to a large number of researches, brain ischemia injury is closely related to the mitogen-activated protein kinase (MAPK) cascade pathway. And C-Jun N-terminal protein kinase(JNK) is an important member of the [...]
Background The acute respiratory distress syndrome (ARDS) is a common clinical mani-festation of acute lung injury (ALI) with a high mortality rat,with an age-adjusted incidence of 86.2/100,000 person-years, with a mortality of 40%, and with significant morbidity among the survivors.Remains one of the major challenges adult intensive care units. ALI/ARDS can lead to sepsis, trauma, [...]
Objective:To study the effects of TMP)on expression of the stimulated HSC-T6; To investigate the mechanisms of anti hepatic fibrosis.Methods:HSC-T6 was cultured with varying doses of TMP and 10ug/l of TNF-αin vitro. Immunocytochemistry was used to test the effect of TMP on expression of ICAM-1 in HSC-T6.Results:1 Compared with blank group, all the TMP groups had [...]
OBJECITVE:To study the effects of tetramethylpyrazine (TMP) on expression of connective tissue growth factor (CTGF), nuclear factor-κB (NF-κB) and related gene product IL-6 in Tumor necrosis factor-α(TNF-α) stimulated hepatic stellate cell-T6(HSC-T6); To investigate the mechanisms of anti hepatic fibrosis.METHODS:HSC-T6 was cultured with varying doses of TMP and 10ug / l of TNF-a in vitro. Immunocytochemistry [...]
High fatality rate is one of the properties of ovarian cancer, since it lacks specific physical symptom, and it’s hard to make a diagnosis at the initial stage. About 70% of patients with ovarian cancer are diagnosed at advantage stage and have metastasis simultaneously. Surgery and chemotherapy are still the main methods to cure ovarian [...]
Objective:In order to observe the expression of apoptosis factor in different tissuewhen wistar rats were thirty-second weeks, neonatal wistar rats were induced by a single intraperitoneal injection of streptozotocin(STZ) to establish an animal model of insulin resistant; using different methods to treat the rats and observe the concentration of apoptosis factor in insulin resistance and [...]
Objective:With the construction of vitro culture system of cartilage cells and the intervention of tetramethylpyrazine(TMP), the experimental results of proliferative activity of cartilage cells and the differential expression of CDK4,CyclinDl help probe the effects of tetramethylpyrazine on growth cycle of cartilage cells, and provide the theoretical evidence for the influence of tetramethylpyrazine on prevention and [...]
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