Objective To reproduce the rats models with incisional pain, compare the analgesia effect of flurbiprofen axetil in rats by giving different doses of flurbiprofen axetil at two time points, discuss the preemptive analgesia effect of flurbiprofen axetil.(1) To observe the rats behavior research and COX-2of spinal cord by injection different doses of flurbiprofen axetil from [...]
Objective Compare the cumulative pain scores and the content of COX-2and TNF-a of parecoxib sodium on the rats with incision pain by giving different doses of parecoxib sodium at two different time point to investigate the preemptive analgesia effect of parecoxib sodium.Methods54male Wistar rats were randomly divided into three parts:control group (K part),the preoperative group [...]
The mechanism of neuropathic pain (chronic) has been a challenge in neuroscience.Clinically, the drugs used to treat chronic pains by simply inhibiting the neurons thattransfer pain signals, have poor efficacy and serious side effects. This suggests that thesensation function of the pain receptors and the transduction function of the pain signals dohave abnormal changes.But the [...]
Objective To investigate expression change of MCP-1in the spinal cord of bonecancer pain rats.Methods34female SD rats weighing180～200g were randomly divided into2groups: Sham group (J group, n=17), Model group (M group, n=17). Rats in J group and Mgroup were respectively injected with10μl Hank’s solution or Walker256breast cancercells (1×10~/ml) into the left proximal tibial medullary cavity. At [...]
[Objective]To measure diffusion tensor imaging(DTI) parameter values of the cervical spinal cord in Normal subjects and patients with cervical spondylopathy. To analyze the influence of the size of Region of Interest (ROI) on the parameter values, the relationship between the parameter values and the degree of spinal cord compression, and the relationship between two parameter [...]
Objective:Diacylglycerol kinase ζ (DGKζ) is an enzyme which phosphorylates diacylglycerol (DAG) to phosphatidic acid (PA) to regulate physical and pathological fuctions. Proinflammatory cytokines produced by microglias, such as tumor necrosis factor a (TNFa), contribute to the inflammatory reaction. To investigate the function of DGKζ in experimental autoimmune encephalomyelitis (EAE) rat and provide new method for [...]
Objective: Amyotrophic lateral sclerosis (ALS) is a fatal neurodeg- enerative disease, characterized by progressive muscular atrophy, weakness and pyramidal signs. Patients usually die in 3-5 years after the onset due to bulbar paralysis, respiratory muscle paralysis or lung infection. It is characterized mainly by the loss of upper motor neurons (MN) or lower MNs or [...]
Objective: Amyotrophic lateral sclerosis (ALS) is a fatal neurodeg- enerative disease, characterized by progressive muscular atrophy, weakness and pyramidal signs. Patients usually die in 3-5 years after the onset due to bulbar paralysis, respiratory muscle paralysis or lung infection. It is characterized mainly by the loss of upper motor neurons (MN) or lower MNs or [...]
Objective Recently it has been demonstrated that intracerebroventricular morphine preconditioning(MPC) could confer protection against injury induced by ischemia in the intact rat heart. To investigate the involvement of adenosine in spinal cord and myocardial in cardioprotective effect of intracerebroventricular morphine preconditioning on rat’s myocardial ischemia reperfusion injury, and the relationship with the inflammatory reaction of [...]
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