ObjectiveTo investigate the expression of (3-APP, NSE and S100B after severe traumatic brain injury in rats.MethodsThe animal model of severe traumatic brain injury including DAI(Diffuse axonal injury) and FBC(Focal brain contusion),made in 67 SD rats,then they were randomly divided into control group(n=7), sham-operated group(n=12) and traumatic group at six time points (6h, 12h,24h,7d,3d, and 14d). [...]
Objective: Study the levels of S100B and NSE in cerebrospinal fluid and serum of patients with Viral Encephalitis (VE) caused by Hand Foot and Mouth Disease (HFMD) and its clinical significance to find the predictors in the progression of severe and critically ill patients.Methods: The levels of S100B and NSE of cerebrospinal fluid and serum [...]
Objective: To explore the neuroprotective mechanisms of r-HuEPO on rats after traumatic brain injury.Methods: 60 healthy adult male Sprague-Dawley rats were randomly divided into 5 groups: 1000U/kg r-HuEPO-treated, 3000U/kg r-HuEPO-treated, 5000U/kg r-HuEPO-treated, nicholin and normal saline (control group) groups. The model was made by improved Feeney’s traumatic brain injury model. Serum samples were collected at [...]
Objective:To investigate the expression and significance of S100B and NF-κBp65 in lacrimal gland,cornea and conjunctiva in diabetic rats.To study the effects of S100B and NF-κBp65 on rats with diabetic dry eye,and the relationship between S100B and NF-κBp65.Methods:35 male SD rats weighted 160-180g,were randomly divided into normal control group(n=5) and diabetic group(n=30).After fasting 48 h,the rats [...]
Part I Effect of different functions of sympathetic nerve on chronically compressed peripheral nerveSympathetic nerve belongs to autonomic nerve system. Anatomically, the postganglionic fiber of sympathetic nerve is a component of peripheral nerve. Under a normal physiological condition, directly anatomical connection seldom exists between peripheral nerve and sympathetic nerve system, and peripheral afferent nerves and [...]
Objective:To investigate the effects of neuropathic pain on the ability of learning and memory, and the level of protein S100B in cerebrospinal fluid(CSF),the change of synaptic structure of CA1 area in the hippocampus.Methods:Total 60 male 18-month-old Wistar rats, randomly divided into 3 groups:normal group (N),sham group(S),CCI group(C),the CCI(chronic constriction nerve injury) model with chronic sciatic [...]
Primary brain-stem injury usually refers to the brain-stem was the chief part of the head injury resulted from violence, and immediately occurred in a longer duration of loss of consciousness and even death. Pathological changes of brain-stem injury such as transaction, contusion, hemorrhage, diffuse axonal injury(DAI) and edema, etc, should occur after brain-stem injury. Besides [...]
Ischemic stroke is a common disease in aged people, it is a major source of increased morbidity, mortality and disability rat, which is a threat to people’s health and results in heavy pressure of spirits and economy on the society and families. In the field of ischemic stroke treatment, thrombolysis is the only effective treatment [...]
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