Objective: AMPKα2plays a very important role in regulating myocardialenergy metabolism. We established the anoxia/reoxygenation injury model andCl–free A/R injury model that Cl-in perfusion solution was replaced with equimolargluconate-during the A/R protocol of H9c2myocytes to explore the role of AMPKα2low expression in acute A/R injury mediated by Cl-. And in order to further study themechanism of [...]
Objectives: To make definite the practicability of sorting and cultivating DCs (dendritic cells) from rhG-CSF(human recombination granulocyte colony stimulating factor ) mobilized peripheral blood, to explore the characteristics and the capability of specifically inducing the anti-tumor immunological effect of dendritic cells (DCs) transfected with human lung adenocarcinoma cell line A549 total RNA through electroporation.Methods: Induced [...]
Objectives: To make definite the practicability of sorting and cultivating DCs (dendritic cells) from rhG-CSF(human recombination granulocyte colony stimulating factor ) mobilized peripheral blood, to explore the characteristics and the capability of specifically inducing the anti-tumor immunological effect of dendritic cells (DCs) transfected with human lung adenocarcinoma cell line A549 total RNA through electroporation.Methods: Induced [...]
Objectives: To make definite the practicability of sorting and cultivating DCs (dendritic cells) from rhG-CSF(human recombination granulocyte colony stimulating factor ) mobilized peripheral blood, to explore the characteristics and the capability of specifically inducing the anti-tumor immunological effect of dendritic cells (DCs) transfected with human lung adenocarcinoma cell line A549 total RNA through electroporation.Methods: Induced [...]
Objective:Pancreatic cancer is a highly malignant tumor of digestive system ,and it is seriously harm to human’s life and health. Because of its hidden disease and rapid progress, the effect of traditional treatment is not satisfactory.Its treatment is very difficult and prognosis is very poor, so it is very important to developed a new method [...]
BackgroundsDental caries is a common oral infectious disease that affect people’s health.One of the dominant pathogenic microorganisms cause human dental caries is Streptococcus mutans(S. mutans), which attaches on the surface of the teeth,produce polysaccharide and acid, and survive acid environment. With the contribution of GGDEF, S. mutans generates c-di-GMP, which has been reported mediating biofilm [...]
ObjectiveIt is one of important mechanism that aberrant cell cycle control causes cell deregulated proliferation in malignant cancer. Skp2 is one of many factors controlling cell cycle, and is paid close attention to increasingly as a new cancer gene. Skp2 is also one important substrate of APC-Cdh1. APC-Cdh1 plays important role on regulating cell cycle, [...]
ObjectiveTo observate the effect of Jiangu Granula in osteocalcin（OCN）、Osterix（OSX）、core binding factor aphal（Cbfal）、alkaline phoSphatase（AKP）、Collagen TypeⅠ（ColI）,hydroxyproline（HYP） and Mineralization tubercle on Rat Osteoblast and research the effects of Jiangu granula （JGG） on OB in differentiation,so that to probe into the detailed mechanism of prevention and cure of postmenopause osteoporosis with traditional Chinese medicine.Methods（1） Establishing the culture in vitro [...]
With the rapid development of structural biology, more and more 3D structures of biomacromolecules have been experimentally determined, which drives Computer-Aided Drug Design (CADD) into the stage of rapid development. Nowadays, owing to CADD techniques integrated into the workflow of drug discovery, the drug research and development have been transferred from traditional random screening to [...]
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