Objectives To observe the effects of Musk-Aconite-Earthworm-pill on pathomorphology and expression of vascular endothelial growth factor (VEGF) and endostatin (ES) of synovium tissue in the rats with adjuvant arthritis (AA), and investigate Musk-Aconite-Earthworm-pill treats the rheumatoid arthritis whether concerns with the adjustment to the imbalance of VEGF/ES.Methods1.Divide group and build model: The Wistar rats in […]

Research purposes:This study through the observation, the evaluation of patients with clinical index (pain joint swelling of the joints, the number of number, HAQ index, etc), biochemical index (rheumatoid factor (RF), blood sedimentation (ESR), c-reactive protein (CRP)), Curative effect evaluation (disease curative effect evaluation, disease activity evaluation), and other changes, Evaluation of far row needles […]

Objective:Aimed to compare the efficacy of two treatments of Active Rheumatoid Arthritis(RA) treatment with pure drug alone and moxibustion combined drugs treatment. Discussed the moxibustion combined drugs treatmetnt on the profit to improve the patients’ symptoms and quality of the life, Observed the influences on the levels of Interleukin-1(IL-1)、Interleukin-2(IL-2)、Interleukin-4(IL-4) and Tumor Necrosis Factor-alpha(TNF-α) in serum. […]

Objective:1 To investigate the effect of Zhengqingfengtongning(ZQ) and methotrexate (MTX), used alone or in combination, on bone erosions of RA;2 To approach the possible mechanisms of ZQ and MTX on bone erosions from the aspect of inflammation and RANKL system.Methods:1 Synovial cell was incubated in vitro. These cells were divided into 3 experimental groups (MTX […]

Objective: Our research aims to evaluate the clinical efficacy and safety of TCM treatment by comparing curative effect indexes and safety indexes between the treatment group and control group. Methods: First for TCM dialectical type, 60 patients were randomly assigned into two groups, 30 in the treated group treated with Chinese and western medicine comprehensive […]

Objective: To observe the relationship between traditional Chinese medicine and leflunomide about the happen of Secondary pulmonary fibrosis in the therapeutic process of Rheumatoid arthritis, and discuss the pathogeny and pathogenesis.Methods: The subject applies the way of reviewing study,and collects 98 cases of Rheumatoid arthritis patients classified into two groups on the basis of different […]

Objective: To observe the clinical effect of Guishao Tongluo decoction in treating RA with simultaneous occurrence of cold and heat syndrome, and discuss the etiology, pathogenesis and therapeutic principle of this syndrome. Methods: By a randomized, controlled method,60cases of RA patients with simultaneous occurrence of cold and heat syndrome were randomly divided into treatment group […]

Background Methotrexate (MTX) has been the drug of choice for rheumatoid arthritis (RA) for several decades. During its Medical practice, it is observed the same dosage of which may achieve varied efficacy on different patients, such phenomenon could not be explained simply by serum drug concentration. MTX convert to Methotrexate polyglutamates (MTXPG) in many cells,such […]

Background: Rheumatoid arthritis(RA) is a chronic autoimmune disease and is characterized by inflammation of synovial tissue and joint destruction. The etiology of RA has not yet been clarified, but it is thought to result from complex interaction of multiple genes and unknown Environmental triggers. Recently, the nucleotide-binding, leucine-rich repeat pyrin domain containing protein 1 (NLRP1) […]

Objective:To investigate the progression of the lipid profile in patients with rheumatoid arthritis and analysis the relationship between dyslipidemia and atherosclerosis.Methods: Taking 85 cases with RA(including 51 actives and 34 inactives)as researching group, and 97 healthy subjects as normal control group,the serum levels of TC、TG、HDL-C、LDL-C、Apo A-I、Lp(a)、FPG in each group and the levels of ESR、hs-CRP in […]