Objective: To investigate the effect of growth inhibition and autophagy of lung adenocarcinoma A549 cells induced by Rh-endostatin (Endostar/YH-16) and Erlotinib in different concentrations and the combined treatment of human lung adenocarcinoma cells line A549, and explore the role of autophagy in the treatment of lung cancer and mechanisms to provide new ideas for the [...]
Lung cancer is one of the malignant tumor with gradually increased incidence in recent years,all sorts of drug-resistant phenomenon greatly limits its clinical curative effect.Therefore,study on the genes involved in resistance and related mechanism will greatly help the treatment of lung cancer.Cisplatin（DDP） is one of the most frequent used chemotherapy drugs for lung cancer,which can [...]
Objective:To observe the effects of Xiaoaiping injection alone and when combined with Oxal-iplatin and rh-Endostain(endostar) to inhibit the growth, metastasis and angiogensis of tumor in nude mice with the high metastatic human HCC transplanted in situ (LCI-D20),and investigate the mechanism of Xiaoaiping injection alone and when combined with chemotherapy and antia-ngiogenic therapy to cure hepatocarcinoma.Methods:Forty-eight [...]
Objective The purposes of research is to detect if rh-Eendostain has an inhibitive effect in the proliferation on human glioma cells.It aims to provide a theoretical basis for the drug screening.Methods (1)Human brain gliomas were cultured under the conditions:at 37℃, P <95% of the air in the DMDM medium. Digesting cells with 0.125% trypsin and [...]
Objectives:To observe and analyze the effect of antitumor and anti-angiogenesis of rh-endostatin. To compare effect of rh-endostatin on microvasculature in tumor, myocardium and renal tissue. To investigate the mechanism of cardiovascular system’s adverse effect of endostar in order to direct it’s clinical application.Method:Nude mice were randomized into 4 groups, blank control group (did not burden [...]
PartⅠThe study on effects of rh-endostatin and docetaxel in phenotypes of HUVECs in different activating levelsObjective:1 To simulate vascular endothelial cell activation,proliferation status in vitro.2 To study the effects of rh-endostatin and docetaxel in phenotypes of HUVECs in different activating levels and further reveal the mechanisms of rh-endostatin.3 To study the effects of rh-endostatin and [...]
Objective To evaluate the safety and efficacy of endostatin (rh-endostatin, YH-16) combined with docetaxel and carboplatin (TP)regimen for the adjuvant treatment of non-small lung cancer (NSCLC) and its impact on circulating blood markers.Methods 36 patients with stage Ib-IIIa 4 weeks after radical resection of NSCLC, were randomly divided into the treatment group, endostatin plus TP [...]
Objective: To investigate the effects and toxicity of recombinanted rh-endostatin combined with Gemcitabine and Platinum regimen for NSCLC.Methods: The 64 cases of Phase IIIB-IV Initial treatment NSCLC from Jan.2005 to Jan. 2010 that met the Inclusion criteria were confirmed by pathology (22 cases were experimental group and 42 cases were control group ), the control [...]
Hello,My name is Jack,Ph.D. Supervisor, Welcome to My WebSite