Objective Though creating the intima injury model of rabbit carotid artery, observing the efficacy of ATRA on the tunica intima proliferation, the expression of MCP-1(monocyte chemotatic protein-1), TLR-4(Toll-like receptor4)in the injury and repair lesion located at the intima of the rabbit carotid artery, in order to study the possible mechanism of anti-inflammation of ATRA and [...]
Objective To establish a stable method for isolation, primary culture and identification of rat alveolar epithelial cells type Ⅱ (AECII).Explore the effect of acrolein on the cell cycle of AECII and to observe the antagonism action of retinoic acid (RA) to acrolein. Method The lung was instilled with4.2u/ml elastinase solution via the tracheal cannula to [...]
BackgrounBackground and objectiveRetinoic acid (RA) has been shown to induce congenital clubfoot in animal models, but it isunknown if the effect of RA on the formation of clubfoot in vivo results from generalized growthretardation or from the specific effects of hindlimb skeletal development.Materials and methodsExperiment were randomly divided into control and experimental groups. Experimentalclubfoot deformity [...]
The Role of Retinoic Acid Signal Transduction Components in Guinea Pig Eyes with Lens Induced Myopia
ObjectiveTo observe the effort of retinoic acid(RA) signal transport system components on lens induced myopia in guinea pig, investigate the level of RA and the expression of retinoic acid receptor-β(RAR-β) and the interphotoreceptor retinoid-binding protein(IRBP) in retina, choroid and sclera of guinea pigs in order to better understand the mechanism by which RA regulates myopia.MethodsSixty-five [...]
The Role of Retinoic Acid Signal Transduction Components in Guinea Pig Eyes with Lens Induced Myopia
ObjectiveTo observe the effort of retinoic acid(RA) signal transport system components on lens induced myopia in guinea pig, investigate the level of RA and the expression of retinoic acid receptor-β(RAR-β) and the interphotoreceptor retinoid-binding protein(IRBP) in retina, choroid and sclera of guinea pigs in order to better understand the mechanism by which RA regulates myopia.MethodsSixty-five [...]
OBJECTIVE: To observe the influence of retinoic acid on the lung damage and expression of keratinocyte growth factor(KGF) and keratinocyte growth factor receptor (KGFR)of neonatal rats exposed to hyperoxia.METHOD: Ninety full term neonatal Sprague Dawley(SD)rats were divided randomly into three groups within 24 hours after birth. Group I:air+ normal saline (NS)group;Group II:hyperoxia(85%02)+ NS group;Group III [...]
Objective To explore the protein changes in serum of the cleft palate disease, the animal model of the retinoic acid induced cleft palate and the comparative proteome analysis were used in this study.Methods Sixty C57BL/6J strains of mice were used in this study. For the experiment group, E10 pregnant female mice were given by gastric [...]
Objective To explore the protein changes in serum of the cleft palate disease, the animal model of the retinoic acid induced cleft palate and the comparative proteome analysis were used in this study.Methods Sixty C57BL/6J strains of mice were used in this study. For the experiment group, E10 pregnant female mice were given by gastric [...]
Background: Tongue plays a critical role in the regulation of midface development especially the palate. At day 14 mouse embryos, tongue become flat gradually and then dropped into the mouth, after that the lateral palate take a rotation and extend toward the horizontal line, contact and fuse. One of the main mechanisms of cleft palate [...]
Background: Retinoic acid-induced cleft palate in mice is a common and reliable animal model to probe the mechanism of congenital cleft palate which is caused by gene-environment interactions.?Retinoic acid realize its function though binding with its membrane receptor into intracellular. Then the retinoic acid binding protein transport it into the nucleus and combine the corresponding [...]
Hello,My name is Jack,Ph.D. Supervisor, Welcome to My WebSite