Background: Retinoic acid-induced cleft palate in mice is a common and reliable animal model to probe the mechanism of congenital cleft palate which is caused by gene-environment interactions.?Retinoic acid realize its function though binding with its membrane receptor into intracellular. Then the retinoic acid binding protein transport it into the nucleus and combine the corresponding […]

Background: Tongue plays a critical role in the regulation of midface development especially the palate. At day 14 mouse embryos, tongue become flat gradually and then dropped into the mouth, after that the lateral palate take a rotation and extend toward the horizontal line, contact and fuse. One of the main mechanisms of cleft palate […]

Objective To observe the influence of all-trans retinoic acid(ATRA) on intimal proliferation and the expression of NF-κB and P-selectin in atherosclerotic plaques and serum IL-1βlevel in rabbits.Methods 54 New Zealand rabbits were randomly divided into 9 groups: sham-operation groups(A,B,C), control groups(A,B,C), treatment groups(A,B,C). There were 6 rabbits in each group. The sham-operation groups were fed […]

Objective:To investigate the mechanism that retinoic acid(RA)protect against hyperoxia-induced lung injury.Methods:Ninety Sprague Dawley rats were randomly assigned into three groups with thirty rats in each group. group A:air contol;group B: hyperoxia group;group C:hyperoxia+RA group. Lungs were removed by tnoracotomy on postnatal 4,7,14 day. Radical alveolar counts (RAC) were observed by HE under light microscope. The […]

Stem cells are a class of primitive cells with self-renewal and multilineage differentiation potential. Forkhead proteins are a class of very important cellular transcription factor involved in cell metabolism, growth, differentiation, proliferation, apoptosis and almost all biological processes.This study focuses on the two members of the Fox family gene FoxA1 and FoxM1 by use of […]

Retinoic acid (RA) plays multiple roles in the nervous system, including induction of neural differentiation, axon outgrowth and neural patterning. Previously, RA for neural differentiation of embryonic stem cells (ESCs) always relies on embryoid body formation. Here we report an in vitro adherent culture system to induce mouse ESC line R1 into neural cells accompanied […]

Objective Though creating the intima injury model of rabbit carotid artery, observing the efficacy of ATRA on the tunica intima proliferation, the expression of MCP-1(monocyte chemotatic protein-1), TLR-4(Toll-like receptor4)in the injury and repair lesion located at the intima of the rabbit carotid artery, in order to study the possible mechanism of anti-inflammation of ATRA and […]

Objective To establish a stable method for isolation, primary culture and identification of rat alveolar epithelial cells type Ⅱ (AECII).Explore the effect of acrolein on the cell cycle of AECII and to observe the antagonism action of retinoic acid (RA) to acrolein. Method The lung was instilled with4.2u/ml elastinase solution via the tracheal cannula to […]

BackgrounBackground and objectiveRetinoic acid (RA) has been shown to induce congenital clubfoot in animal models, but it isunknown if the effect of RA on the formation of clubfoot in vivo results from generalized growthretardation or from the specific effects of hindlimb skeletal development.Materials and methodsExperiment were randomly divided into control and experimental groups. Experimentalclubfoot deformity […]

ObjectiveTo observe the effort of retinoic acid(RA) signal transport system components on lens induced myopia in guinea pig, investigate the level of RA and the expression of retinoic acid receptor-β(RAR-β) and the interphotoreceptor retinoid-binding protein(IRBP) in retina, choroid and sclera of guinea pigs in order to better understand the mechanism by which RA regulates myopia.MethodsSixty-five […]