Objective:Cardiovascular and cerebrovascular diseases have become the major diseases that threaten human health, atherosclerotic is the main pathological basis of cardiovascular and cerebrovascular diseases. Endothelial dysfunction, smooth muscle cell proliferation, platelet aggregation and thrombosis activation are the main pathogenesis. Currently preventing the occurrence and development of atherosclerosis has become a focus of the study. In [...]
Objective:Cardiovascular and cerebrovascular diseases have become the major diseases that threaten human health, atherosclerotic is the main pathological basis of cardiovascular and cerebrovascular diseases. Endothelial dysfunction, smooth muscle cell proliferation, platelet aggregation and thrombosis activation are the main pathogenesis. Currently preventing the occurrence and development of atherosclerosis has become a focus of the study. In [...]
OBJECTIVES: To determine the learning and memory ability and the morphous, explore the role of angiotensin converting enzyme (ACE), two subtypes of angiotensin II receptor (AGTR) that is AGTR1 and AGTR2 in the hippocampus of alzheimer disease (AD) model rats, and to approachthe effect of perindopril – angiotensin converting enzyme inhibitor (ACEI) and valsartan -angiotensin [...]
Objective: In humanbeings, various kinds of vital phenomena show some degree of biological rhythms and the most frequent was the carcadian rhythm with period of approximately 24 hours. The cardiovascular system is organized according to an oscillatory pattern, and most cardiovascular functions, such as blood pressure, exhibit typical circadian rhythm. Recently, it has been found [...]
Objective: This study evaluates the antihypertensive efficacy and safety of the novel oral renin inhibitor aliskiren.Methods: The study was a randomized, double-blind, active-comparator trial in 118 patients with mild-to-moderate hypertension (mean sitting diastolic blood pressure [msDBP]≥90mmHg and<110mmHg). After a 2-week, single-blind placebo run-in, 109 patients (mean sitting diastolic blood pressure [msDBP]≥95mmHg and<110mmHg)were randomized to receive [...]
ObjectiveTo study the levels of noradrenaline (NE )、adnephrin(E)、angiotensinⅡ(AngⅡ)and rennin (PRA) in acute phase of SHR (Spontaneously hypertensive rats)with hypertensive intracerebral hemorrhage(ICH),dicussing the relationship between blood-pressrue regulation and NE、E、PRA、AngⅡin center and periphery after acute intracerebral hemorrhage of SHR.MethodsThe ICH model was established by infusing collagenase into rat caudate nucleus.The changes in NE、E in plasma and hypothalamus [...]
Objective: Biological rhythms are a universal phenomenon in living organisms. In humanbeings, various kinds of vital phenomena show some degree of biological rhythms and the most frequent was the carcadian rhythm. Recently, it has been found that the abnormal rhythms of blood pressure not only increase the risks of target organs damage but also increase [...]
Part I Inhibitory Effect of Resveratrol on Proliferation ofLeukemic CellsObjective: To investigate the effect of leukemic cellsproliferation, cell cycle and apoptosis by resveratrol and make the theoretics and experiment basis for reveratrol as an antileukemia drug.Methods: Human K562 leukemia cells were cultured in RMPI1640 mediumsupplemented with 10% fetal bovine serum in 37℃, 5%CO2 humid incubator. [...]
Part I The Induction of Rat Models of Acute Edema Pancreatitis and Necrotic Pancreatitis.Objective To induce rat models of acute edema pancreatitis(AEP) and acute necrotic pancreatitis(ANP). To provide rat models for the second and the third parts of this study. Methods Thirty Sprague-Dawley rats were randomly divided into three groups, control group, AEP group and [...]
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