Objective:Detect and analyze the therapeutic effect of bone marrow mesenchymal stem cells which carry human vascular endothelial growth factor-165 (hVEGF-165) gene on hind limb ischemia, and provide new ideas for the clinical treatment of lower limb’s ischemia.Method:The experiment set up three groups, which were group BMSC carrying hVEGF-165 gene, group BMSC and blank control group, [...]
Objective:To observe and analysis anti-gout capsule effects and the machanism on acute gouty arthritis (GA) in rats.Methods:Fifty rats were randomly divided into five groups:control、model、positive controlcochicine (0.8mg/kg)、low dose anti-goutcapsule(0.3g/kg) and high dose anti-gout groups(1.2g/kg), Besides control group, the gout model was made in other groups by injected sodium urate into joint cavity, Intragastirc administration of anti-gout [...]
Objective:To investigate positive effect of CRMP1 gene on neurite outgrowth and cytoskeleton in rat hippocampal neurons.Materials and methods:The three-pair siRNAs acquired via chemical synthesis were screened by RT-PCR and real-time PCR. The effective siRNA interfering CRMP1 gene was supported by immunocytochemical and western blot. The fluorescence radix FAM was constructed upon 5′terminal of the siRNA, [...]
ObjectiveFood Additives alum (potassium aluminum sulfate) closely related to people’s daily lives, are widely used in fried foods, fermented foods, puffed food, and pickled seafood, vermicelli and other produce. Currently the excessive use of alum in the process of food processing and production is severely, resulting aluminum element content of food higher than the national [...]
Objective:To study the antioxidant effects of picrosideⅡon the cerebral ischemia reperfnsion injury in rats and provide theoretical basis of picrosideⅡin clinical application.Methods The MCAO/R models were establish with a suture blocking in the MCA in 100 healthy Wistar rats and were randomly divided into sham operative group, negative control group, positive control group and drug [...]
Objective:In this study we investigate the effects of erythropoietin(EPO) on the ex-pression of 5-bromo-deoxyuridine(BrdU) in dentate gyrus(DG) region and glial fibri-llary acidic protein(GFAP) in CA1 region after hypoxic-ischemic brain damage(HIB D) in neonatal rats,to explore the neuroprotective effects of erythropoietin according to the regeneration of neurocytes and the improvement of learning and memory ca-pability by [...]
Objective In this study we investigate the effects of erythropoietin (EPO) on the expression of 5-bromo-deoxyuridine (BrdU) in subgranular zone (SGZ) and Nestin in dentate gyrus (DG) after hypoxic-ischemic brain damage (HIBD) in neonatal rats, to explore the neuroprotective effects of erythropoietin according to the regeneration of neurocytes and the improvement of learning and memory [...]
Objective:With the guide of traditional Chinese medicine theory and modern medical theory, this experiment explores Zexie Tang lipid-lowering mechanism by observing the influence which the different concentrations Zexie Tang act on experimental hyperlipidemia rats after we establish a stable, convenient hyperlipidemia rats model, and provides scientific basis for lipid-lowering and reference for clinical medicine.Methods:60 only [...]
ObjectiveWe explore the mechanism of the restriction of recurrence of endometriosis (EMs) using the herbal medicine of HuoXueXiaoYi through observing the changes of the ectopic endometrium volume, the pathologic, and the expression levels of ICAM-1,MMP-9,VEGF.MethodsGroup:Seventy SD female rats were randomly divided into seven groups and every group has ten rats. There are one normal control [...]
Objective:To estibalish the rats model of high-altitude pulmonary edema by putting Wistar rats in hypobaric chamber, the severity of pulmonary edema in different group was compared.Methods:Male Wistar rats were randomly divided into three groups:control group,24 h hypoxia group,48 h hypoxia group. Except for the control group,rats in the other groups were put in a hypobaric [...]
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