BackgroundDaunorubicin is an anthracycline antibiotics, as the basic drug of clinic chemotherapyscheme because of its damage DNA, inhibit the topological isomerase Ⅱ (Topo Ⅱ) role.Butwith strong side effects, and happened resistance and recurrence easyly, make its applicationsubject to limit, the mechanisms of resistance may is NF-kB signal path abnormal activation andcause cells resistant gene expression [...]
BackgroundOsteosarcoma is a common malignancy in clinical accounts for about20%of primary bone tumors. Because of the high degree of malignancy of osteosarcoma, the rapid rate of progress and the characteristics of vulnerable to relapse and metastasis, its Treatment is very poor. Although Osteosarcoma of the jaw accounted for5%of the oral and maxillofacial malignancies, with the [...]
Objective:In order to further research the suppression of has-miR-99a on proliferation ofhepatocellular carcinoma cells through constructing adenovirus vector.Methods:Expression of miR-99a was detected by quantitative real-time polymerase chainreaction (qRT-PCR) in HCC. The adenovirus vector Ad5-miR-99a were constructed.Through the Luciferase Reporter Assay found that miR-99a regulation of the new target genesEIF2C2. Then we detected EIF2C2and downstream PTEN [...]
Objects:To detect the expression of Beclin1and PTEN in gastric caicinoma, andinvestigate its influence in carcinogenesis of gastric mucosa and prognosis.Methods:The tissue micioarrays containing199cases of gastric tumor specimens werefollowed up by telephone again in this study to get the survival data,while collecting15pairs of fresh gastric carcinoma and matched adjacent normal tissues for experimentalstudy.Using immunohistochemistry (IHC),Western blot [...]
[Objective]:To evaluate the inhibitory effect of Survivin antisense oligonucleotide (ASODN)on nude mice bearing human pancreatic carcinoma xenograft;the expression of Survivin PTEN、CEACAM-land Cox-2, and their correlation in pancreatic cancer.[Methods]:Twenty-eight nude mouse models bearing human pancreatic carcinoma xenograft were constructed and randomly assigned to control group, Lip group, SODN group and ASODN group. Each group has seven [...]
Gallbladder cancer is one of the most common malignancies in biliary system，In recentyears, its incidence is rising，Because the early symptoms of gallbladder cancer is hidden, mostpatients have been developed to middle-late stage at time of diagnosis, operation is difficult toradical resection, 5 years of survival rate is low. So far, the occurrence and development ofmechanism [...]
Background and PurposeThe gastric cancer is still large harm on human body by a high incidence of high mortalityfrom diseases. The cause of stomach cancer occurrence factors of physical and chemical factors,chemical factors in our country occupies the main position. Researchers pay much attention tothe study of cancer biological pathways, such as apoptosis, cell cycle [...]
Objective: PTEN is a protein that has lipid phosphatase activity and anti-tumour activity. It isa tumor suppressor gene with a dual-specificity phosphatased activity, which can maintain thestability of intracellular environment and the normal metabolism. Its low or lacking expressionis closely related to tumor development and progression. Autophagic level of tumor wascorrelated with the expression of [...]
Objective:This topic to be of primordial follicles in vitro culture model to explore theregulation of primordial follicles initiation and growth of an important gene ptenexpression in primordial follicles, and used the carrying of pten-shRNA lentiviralvector to transfect vitro ovary, observed pten down impact the initiation and growthof primordial follicles, and then explore the pten in [...]
[Objective]To study the expression and significance of EGFL7 and PTEN in human glioma tissues,in order to evaluate influences of the expression and significance on neovascularization and FAK-phosphorylation.[Methods]The expression of EGFL7 and PTEN in 56 cases of human glioma and 8 cases of normal brain tissues were detected by immunohistochemistry test (SP method) and their correlations [...]
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