Objective Research propofol on liver ischemia reperfusion rat liver tissue toll like receptor4(TLR4) and nuclear factor-JB (NF-κB) and serum tumor necrosis factor-a (TNF-a), and investigate the effects of propofol postconditioning acute liver injury induced by ischemia reperfusion in rats and possible mechanisms.Methods Sixty healthy Wistar rats not discriminated female and male, weighting200-250g were randomly divided [...]
ObjectiveThe observation of the expression of S-100β protein and NSE during the process of bilateral middle carotid stenosis rabbits’ ischemic brain damage and the discussion of the effects propofol to ischemic brain damage caused by low blood pressure, provide the theory basis for the application of propofol in Clinical anesthesia.MethodsAny male and female Eighteen healthy [...]
Objective Establish rat70%hepatic ischemia-reperfusion model, injecting propofol to postconditioning on the model, observe the change of histomorphology,the expression of Bc1-2and Bax protein and the apoptosis index (AI) of hepatic cells, and investigate the effects of propofol postconditioning intervention on the ischemia reperfusion injury (IR) in rat livers.Methods Sixty Wistar rats,weighting200-250g,were randomly divided into5groups(n=12):(1)sham operation group(Group [...]
ObjectiveTo discuss the feasibility of dexmedetomidine and laryngeal mask airway in awaken craniotomy. Comparing the advantages and disadvantages between propofol combined with dexmedetomidine for asleep-awake anaesthesia during the Narcotrend monitoring, in order to provide more choices for selecting anaesthesia methods of awaken craniotomy.Methods1Sixty patients undergoing:Group A:proporol+dexmedetomidine (0.2u g. kg-1·h-1).Group B:proporol+dexmedetomidine (0.4μg. kg-1·h-1). Group C:proporol+dexmedetomidine (0.6μg. [...]
Obiective：The purpose of this study is to investigate the role of PKCs in medatingpropofol-induced eNOS phosphorylation and subsequent NO production in humanumbilical venous endothelial cells (HUVECs).Methods：Cell within passages2to5were used in all experiments. To determinewether propofol has an effect on eNOS activation, HUVECs were treated with propofol(1-100μmol/L) for up to24hrs, and phosphorylation of eNOS at serine1177was [...]
Background:This study was to discuss the mechanism about that epidural lidocaine blockade (the same dose of lidocaine) intensify the sedative and hypnotic effects of propofol anesthesia.Methods:66patients, undergoing gastric or intestine surgery were randomly enrolled into this study. All patients were randomly assigned to the following four groups: epidural saline control group (Group C, L2-L3, epidural [...]
Objective:To investigate the effects of propofol and sevoflurane and one-lung ventilation time on cerebral oxygen saturation Methods: According to the ASA classification, we choose58patients who belong to ASA Ⅰ-Ⅱ and seperate them in two groups randomly. Each group contains29patients. Both of these two groups accept the same derivatives. In group P, using propofol TCI3.5-4.0ug/ml for [...]
Objective To compare the effect of sedation of combined spinal-epidural anesthesia and epidural anesthesia.Methods A randomized controlled trail was conducted on60patients undergoing selective gynecological abdominal surgery.Women were randomly divided into combined spinal-epidural anesthesia sedation group (group SE) and epidural anesthesia sedation group (group E). The sensory block level was controlled between T6and T8,the TCI of [...]
Backgrounds and ObjectivesDezocine appeared in the domestic market in2009, which is a new type of mixed opioid receptor agonist-antagonist. it is mainly excited κ receptors to produce analgesia and partially antagonize μ. receptor, because of this, it have minimal impact on the respiratory system. Compared with the pure opioid receptor agonists following are some differences:①analgesic [...]
Objective:To compared the effect of sevoflurane-remifentanil and propofol-remifentanil on cell apoptosis induced by hepatic ischemia reperfusion injury.Methods:Anesthesia for elective resection of 40 patients who had the right liver with hepatic occlusion Parallel, aged 30-70 years old, weighing 40-80 kg,ASAⅡ-Ⅲlevel, liver function Child A class.We randomly divided into 2 groups:sevoflurane-remifentanil group (group S) and propofol-remifentanil group [...]
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