Heart failure (HF) is the end-stage state of various cardiovascular diseases. Patients with HF are characterized by deteriorated cardiac function, impaired labor ability, and unacceptably high mortality, thus HF have made a serious health problem which threats the public society. Hypertension is a major pathogenic factor which leads to heart failure. According to the China [...]
Heart failure (HF) is the end-stage state of various cardiovascular diseases. Patients with HF are characterized by deteriorated cardiac function, impaired labor ability, and unacceptably high mortality, thus HF have made a serious health problem which threats the public society. Hypertension is a major pathogenic factor which leads to heart failure. According to the China [...]
Cardiac hypertrophy is the response to long-time pressure or volume overload, which can be sort to early compensatory and late decompensated cardiac hypertrophy. In the situation of pressure overload,the myocyte goes through hypertrophy to overcome the increased afterload and maintain normal cardiac function. A lot of factors participate in the process of heart failure, which [...]
Objective: To investigate the characteristic of the extracellular matrix remodeling induced by left ventricular pressure overload in valve disease. To analyze the gene expression of CTGF and MT1-MMP mRNA in cadiac muscle induced by pressure overload in valve disease, and the mechanism of CTGF and MT1-MMP in extracellular matrix remodeling. To identify the relationship between [...]
Objective: To investigate the effects of decreasing autophagic activity on cardiac hypertrophy and pathological declines in systolic performance in rats triggered by pressure overload.Methods: Pressure overload induced by abdominal aortic banding .Twenty-six male SD rats were subjected to third groups at random: control group, model group, 3-MA group. The left ventricular and function indexes of [...]
Background: Mortality rate of chronic heart failure (CHF) remains high despit optimal therapies and there is still a great need in exploring novel potential therapeutic targets. Recently, results from the African-American Heart Failure Trial (A-HeFT), which demonstrates signficant beneficial effects by a combination of hydralazine (HYD) and isosorbide dinitrate (ISDN) in addition to current optimal [...]
Cardiac hypertrophy is an adaptive response of the heart to pressure overload, prolonged cardiac hypertrophy may result in cardiac dysfunction leading to subsequent cardio- vascular events, such as congestive heart failure and sudden death. The molecular response to pressure overload is complex and may include modulation of various intracellular signal pathways, such as activation of [...]
Background and AimsMyocardial remodeling,including cardiomyocyte hypertrophy and extracellular matrix proliferation chiefly,is the pathological basis of the progression nearly all of cardiovascular diseases.Even though myocardial remodeling is compensatory for cardiac function initially, continuing hypertrophy of myocardium may result in myocardial ischemia,cardiac dysfunction and arrhythmias.The molecular mechanisms of myocardial hypertrophy are the nucleus gene expression alteration stimulated [...]
Cardiac hypertrophy is an adaptive response of the heart to virtually all forms of cardiac diseases, including those arising from hypertension, mechanical load, myocardial infarction ,cardiac arrhythmias, endocrine disorders, and genetic mutations in cardiac contractile protein genes. While the hypertrophic response is initially a compensatory mechanism that augments cardiac output, hypertrophy can lead to dilated [...]
Hello,My name is Jack,Ph.D. Supervisor, Welcome to My WebSite