Objective:To investigate pharmacokinetics of hepatic arterial chemoembo-lization by gelatin sponge particles combined with epirubicin in a rabbit VX2 liver tumor modelMethods:Twelve successful models of VX2 transplantation liver tumor in New Zealand white rabbits was established by directly embedded VX2 cancer tissue particles into rabbits liver, which were divided into two groups randomly,HAI group (n=6):the epirubicin [...]
Lamivudine is a nucleoside drug for anti-HBV treatment. It has a rapid and marked inhibition to HBV DNA,and has a significant improvement to liver function. Protocatechuic acid is a water-soluble phenolic constituents. It has a obvious effect on anti-hepatitis B virus. After the study of pharmacodynamics and pharmacology for amivudine and protocatechuic acid,Our laboratory found [...]
Curcumin is a yellow colored polyphenol with anticancer, anti-inflammatory, anti-virus and antioxidant activities. Its low water solubility, unstablity, quick metabolism and lower bioavailability limited its development and usage. So, how to overcome its shortcoming and improve curcumin’s bioavailability and reduce its dosage has been an urgent problem to resolve for researchers.Amphipathic copolymer composed of hydrophilic [...]
Pulsed oral drug delivery system is based on chronopharmacology and chronopharmacokinetic principles, it’s a a new type of delivery systems of timely releasing doses of effective drug. It can be baed on certain disease’s characteristics of biological rhythm, according to the the idea of time therapeutics. Quantitatively release drug on time to improve patient treatment’s [...]
To evaluate the safety and obtain the pharmacokinetic characteristics of selamectin in animals which is helpful for clinical use, acute toxicity test, irritation test, sensitivity test and bioequivalence were conducted in this thesis.Acute toxicity test of selamectin raw materials and preparations were conducted with Karber method following oral and topical administration in mice and rats. [...]
Background:Voriconazole is a new second-generation triazole antifungal agent, which undergoes a metabolism involving cytochrome P450(CYP) enzyme isoforms CYP2C19 and CYP3A4. However, Chinese people possess a very low frequency of polymorphism in CYP3A4. CYP3A4 and CYP3A5 often affects same substrate drug’s pharmacokinetics together. Studies have shown that CYP3A5 and CYP2C19 do exist gene polymorphism and play [...]
Objective:Study the compatible stability of shuanghuanglian powder injection and common injection in vivo and in vitro, increasing the accuracy to resolve adverse effects of Chinese medicine injections and ensuring the clinical safety of drugs.Method:The samples of complexes with the Sodium chloride solution as a solvent were collected at room temperature to study the changes of [...]
China has rich resource of Chinese medicine, an effective way to search new drugs is searched for active ingredients in traditional Chinese medicine prescriptions, and synthesized by chemical methods. It is also one important way for innovative drug research.According to the treatment of promoting blood circulaton by Chinese medicine, Prof.Tan Zaiyou had separated and extracted [...]
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