Backgroud and objectBronchioloalveolar carcinoma is classified as a subtype of lung carcinoma. In 1999 and 2004, the World Health Organization defines BAC as lesions with lepidic growth without stromal, vascular and pleural invasion.According to this strict definition, BAC is carcinoma in situ.Serious pathological analysis of the lesion should be conducted to exclude infiltration and metastases [...]
ObjectiveTo probe into expressions of p53 protein, p16 protein as well as nm23 protein, and the correlation between expression of p53 protein, p16 protein as well as nm23 protein and clinical pathological factors of lung cancer as well as prognosis, rendering an impersonalevidence for the early diagnosis, early therapy, and prognosis estimation.MethodsThe expressions of p53 [...]
Objective:To investigate the expression of PI3K and P53 protein in prostate cancer (Prostate cancer, PCa) and benign prostatic hyperplasia (Benign prostatic hyperplasia, BPH) tissue, and to explore the clinical significance of the PI3K and P53 in prostate cancer.Methods:The expression of PI3K and P53 in 30 prostate carcinoma and 30 benign prostate hyperplasia was detected with [...]
[Objective] To evaluate the clinical efficacy and toxicity of two regimens of DCF (or DF) or FOLFOX as adjuvant chemotherapy in patients with curatively resected gastric carcinoma; To explore the expressions of P53、EGFR、HER-2、VEGF、PTPRO in gastric carcinoma and to explore potential molecular predictors of therapeutic effect and recurrence risk.Method Patients in Chinese PLA General Hospital from [...]
Objectives:To determine the expression of proteins and mRNA of hPOTl and p53 in gastric carcinoma and investigate their significance in occurrence and development of gastric carcinoma,as well as their clinical significance and the possible mechanism of carcinogenesis caused by HP infection.Methods:The expression of hPOT1 and P53 proteins were detected in 53 gastric carcinoma specimens by [...]
Objective:1.Through analyzing the relationship between VEGF, P53 gene expression level in peripheral blood and syndrome differentiation in colorectal cancer,to provide some ideas for curing the colorectal cancer with the combination of chinese medicine and western medicine, and look for the junction of traditional chinese medicine and western medicine from molecular biology angle;2.To analyze the changes [...]
Objective:Preliminarily explored the distribution of syndromes elements of advanced colorectal cancer, as well as its relation to objective indexs.Methods:Adopting syndrome element differentiation to study the common syndromes elements distribu-tion of advanced colorectal cancer,and we also detected 90 patient’s serum tumor markers and p53 and nm23 gene in peripheral blood,and explored the relationship among syndromes elements, [...]
Sea cucumber, an important food and medicine resource, has lots of bioactive substances, such as sea cucumber polysaccharide, saponins, collagen proteins and cerebrosides. The sea cucumber polysaccharide is one of the most important bioactive substance, and weight about 7%-10% of the body wall of the sea cucumber. There are sea cucumber chondroitin sulfate (SC-CHS) and [...]
Objective:To investigate the relationship between RAD51 G135C polymorphism, Jung cancer risk,pathological characteristic, and p53 mutation in lung cancer.Methods:A total of 80 lung cancer cases and 40 controls with lung non-neoplastic diseases were collected. We analyzed the genotypes of RAD51 (135GC) by PCR-RFLP and detected the p53 mutation of 80 lung cancer cases by imnunohistochemistry,then determined [...]
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