Object ivesIn the present research, we aim at:1. Evaluating the effect of atractylodes macrocephala on the proliferation of normal IEC-6cells and DFMO-induced growth inhibitory IEC-6cells;2. Evaluating the effect of atractylodes macrocephala combined with licorice on the proliferation of DFMO-treated IEC-6cells;3. Examining p21and p53mRNA and protein expression after administered atractylodes macrocephala alone or combined with licorice [...]
Objective To approach the association between the mRNA expression ofASPP family genes and cisplatin chemotherapy sensitivity in gastric cancercells of different p53genetic background. To approach the influence ofcisplatin chemotherapy sensitivity to gastric cancer cells of different p53genetic background after the mRNA expression of iASPP weredownregulated.Methods （1）Gastric cancer cell lines AGS (wild-type p53) andSGC-7901(mutant-type p53) with [...]
Objective:To observe the expression of mutational PBRM1and mutational P53in different stages and classification of renal cell carcinoma (RCC) and normal tissue,to discuss the expression of PBRM1and P53in RCC and their correlation.Methods:Expression of PBRM1and P53was detected by immunohistochemical technique in66cases of RCC and20cases of normal renal tissues,Selected24cases fresh renal clear cell carcinoma samples and10cases of normal [...]
Breast cancer is one of the most common malignant tumor endanger women’shealth. It is occurred in the women who are40to60years old and premenopausal andpostmenopausal. In recent years, breast cancer incidence and mortality are of theupward trend, that is serious harm to women’s health, And has the growing concern bythe people. There are a variety of [...]
Research objectiveTo study the expression of Suivivin and P53gene in bladder adenocarcinoma, explore their roles and relationships in its occurrence and development,expect to get aids for diagnosis, treatment and predicting prognosis in patients with adenocarcinoma of the bladder.MethodsExpression of Survivin and P53protein were detected by immunohistochemical S-P method in40cases of bladder adenocarcinoma tissue,10normal bladder mucosa [...]
Objective:To investigate the expression of PTTG、VEGF、p53、TSP-1。MVD (evaluated by CD34) in Colorectal carcinoma and to explore the relationship beteween PTTG、VEGF、p53、 TSP-1and MVD and clinical parametersMethods:Using immunohistochemical En Vision staining method,the expression of PTTG,VEGF,p53,TSP-1and MVD were detected in18normal tissue,20colorectal adenoma,44colorectal adenocarcinoma, and the statistic method was used to analyze the expression of PTTG correlated with the expression [...]
Objective To study the expression of p53, ki-67in the tissues of hepatocellular carcinoma (HCC) and the relationships between them and clinical pathology and the prognosis of patients with primary HCC after R0resection.Methods (1)The expressions of p53ki-67in HCC tissues of290patients,81cases with adjacent non-cancerous tissues and79cases with cirrhotic tissues were examined by tissue microarray and immunohistochemistry PV-6000methods.(2) [...]
Objective:In composite Alzheimer’s disease (AD), animal models based on. The observation ofhuperzine A to improve the complex learning and memory ability of AD model rats andexplore the learning and memory huperzine A to improve the composite AD model rats,respectively, from the perspective of the serum oxidative stress indicators and brain cells,cyclin ability of possible mechanisms, [...]
Millions of people around the world are infected with HBV, particularly in China. Itis estimated about50%of people infected with HBV come from China, and they arehighly related with occurrence of cancer in liver. So some research on HBV are paidmuch attention, but we still have little knowledge of variation and molecular mechanismspartly owe to lack [...]
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