ObjectiveChina has been regarded as one of the countries suffering seriously from the prevalence of endemic flurosis which becomes a regional disease widely spreading around the world.The research concerning the influence of the combination of selenium and vitamin C on endemic fluorosis has not yet been reported. Based on the individual effect of selenium and [...]
Backgroud and Objective:Diabetic nephropathy is one of the common chronic microvascular complications of diabetes mellitus, and it is also a major etiology of end stage renal disease. So it is important to explore the pathogenesis of diabetic nephropathy and look for early preventing drugs. The pathogenesis of diabetic nephropathy has not yet been fully elucidated. [...]
Objective:To investigate the effects of UCP2 and its posssible mechanisms in IR induced renal injury of mice by examing the expression of UCP2 mRNA and protein as well as its relationship with MDA.Methods:Twenty-eight male C57/BL6 mouses were divided randomly into normal control、IR1、IR2 and IR3 groups(n=7).All of the mouses were intraperitoneal injectied pentobarbital for anesthesia and [...]
Objective:To explore the effects of low dose of spironolactone on the urinary 8-iso-prostaglandin F2a(8-iso-PGF2a) and the ratio of urine albumin to cretine(ALB/CR) in type 2 diabetic patients with early diabetic nephropathy.Methods:42 type 2 diabetic patients with the third stage of diabetic nephropathy were enrolled in and divided into treatment group (Group T, n=21) and control [...]
BackgroundHealth in our country is seriously threatened by cancers and cardiovascular diseases which take up the first and second place in proportional mortality.the world health organization predicts that cardiovascular and cerebrovascular diseases will become the biggest cause of death. How to prevent and control cardiovascular and cerebrovascular diseases will be the chief mission of epidemiology. [...]
Objective To investigate the protective effects of glutathione (GSH) on hydrogen peroxide (E2O2)-induced cell death and matrix destruction in human nucleus pulposus cells.Methods Human nucleus pulposus cells were cultured in alginate beads. Firstly, alginate beads were treated by different doses of H2O2. Prepare hydrogen peroxide-induced cell death and matrix destruction in cultured human NP cellmodel. [...]
ObjectiveInhalable particles, a collection of different types of chemicals as principal atmospheric pollutants, cause many healthy issues, among which toxic effects on cardiovascular system has become one hot topic. According to WHO report, the pollution of fine particles (PM2.5) results in at least 0.8 million deaths and 6.4 million disability adjusted life year (DALY) losses [...]
Objective:To investigate the renoprotective effects of DNL on nonenzymatic glycation and oxidative stress in the diabetic rat kidney. Methods:After a DM rat model was induced by streptozotocin. DM rats were randomly divided into these groups:diabetic control group, DNL low dose group, DNL moderate dose group, DNL high dose group and AG control group;in addition, set [...]
Study of Correlation between 1,5-Anhydroglucitol, Glycemic Excursion and Oxidative Stress Activation
ObjectiveTo analyze correlation of 1,5-anhydroglucitol(1,5-AG), short-term glycemic control, glucose fluctuations and oxidative stress activation.Methods1. From March to July in 2010, according to ADA 2003 diagnostic criteria,281 individuals with normal glucose regulation and other metabolism were recruited from Beijing community or outpatients of Chinese PLA General Hospital. Serum 1,5-AG levels were meagured with GlycoMark.2、Thirty-eight outpatients with [...]
Background and objectivesIn the past studies, it is shown that oxidative stress has been an important factor to be involved in the development of many diseases. Recent studies pointed out that the product of oxidative stress such as active oxygen can affect electrical remodeling and structural remodeling in atrial fibrillation. In atrial fibrillation the produce [...]
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