Objective:To study the mechanism of fine particulate matter(PM2.5) damaging endothelial cell from oxidative pathway. And to show the efficacy and mechanism of ginsenoside Rgl on the inhibition of endothelium injuries by exposure to PM2.5. Moreover, to reveal the variation of Nrf2and HO-1in the Nrf2-ARE signaling pathway from the molecular and gene levels.Methods:Human umbilical vein endothelial [...]
Background The chronic inflammation and oxidative stress in the airway, lung parenchymaand pulmonary vascular is the main characteristics of chronic obstructive pulmonary disease(COPD). COPD is frequently coexist complicated with comorbidities other diseases, such ascardiovascular disease, osteoporosis, and body weight loss. but However, the causal link remainsunclear. Adiponectin is a protein produced and secreted almost exclusively [...]
Diabetes and diabetes chronic complication is a serious disease for human health. At present, cassia seed on diabetes complications is mainly on the compound recipe treatment. In order to study the mechanism of traditional Chinese medicine, this article mainly studies on the single tradition Chinese medicine herb cassia seed on the activity of anti-diabetic complication [...]
Objective: These experiments were carried out to explore the role of ferric ion inosteoclast differentiation and bone resorption as well as to elucidate the underlyingmechanism which might be favorable to further clarify the relationship between ironmetabolism and bone metabolism.Methods:1.RAW264.7was taken as the pre-osteoclast and ferric ammonium citrate(FAC) was used as the donor of ferric ion. [...]
Background and Objective:Alcoholic liver disease (ALD) is a chronic liver disease induced by long-term alcohol abuse, the incidence of which is pretty high in Western Countries. Recently, with development of economy, improvement of living level and modification of life style, the number of alcoholic is increasing, and the incidence of ALD assumes year by year [...]
Objective:To investigate the effects of different dosages of dexmedetomidine on perioperative inflammatory response and oxidative stress in patients undergoing one lung ventilation (OLV).Methods:Thirty-six ASA I or II patients aged43-72yr weighing50-78kg scheduled for esophagectomy were randomly divided into3groups(n=12each):control group (group C), low dose dexmedetomidine group(group D1) and high dose dexmedetomidine group (group D2). Dexmedetomidine1μg/kg was injected [...]
Disbalance of redox homeostasis may be responsible for chemotherapyresistance of cancer. Muti-functional protein p62/SQSTM1is involved in the processof clearing ubiquitinated proteins and regulation of antioxidative signal. Our previousstudies found that the expression of p62was highly expressed in cisplatin-resistanthuman ovarian cancer cells. Therefore, VK3was used to observe its effect onSKOV3/DDP cells and the change of redox [...]
Objective:Oxidative stress, induced by many conditions or events, plays a key role in the pathogenesis of male infertility. This investigation was:(1) To investigate role of Clauaidinll on the spermatozoal dysfunction induced by oxidative stress;(2) To investigate the relative roles of Claudin-3, Claudin-11, key sertoli cell factors in the establishment of the blood-testis barrier (BTB), and [...]
Myocardial ischemia reperfusion injury （MIRI） refers to restore ischemic heart muscletissue perfusion, cause reperfusion area myocardial cell and local blood vessels nets have asignificant pathological changes of physiological, these changes common function can leadto further tissue damage.IL-1ra-Fc-IL-18BP is to IL-18binding proteins （IL-18BP） and IL-1ra connectedthrough the Fc period, the molecular completely different from IL-18BP and [...]
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