Objective To study the mechanism of the expression of MMP-2 gene and the effect on the activity of MMP-2 induced by FN on Hela cell. To discuss whether the Ganoderma polysaccharide can inhibit metastasis of tumor through inhibiting the activity of MMP-2. Methods Hela cell was cultured in RPIM1640 without calf serum and FN worked [...]
Background and Objective The goals of this study were to image oncogene c-erbB2 using 99mTc-radiolabelled antisense oligodeoxy-nucleotides(ASODN) to bind complementally target gene to diagnose breast cancer. The target of antisense oligonucleotide is amplification ribonucleic acid mRNA of mammary tumor protooncogene c-erbB2. 9 mTc-ladled ASODN was connected with epidermal growth factor(EGF) to enhance uptake percentage of [...]
Being one of the most harmful genital malignant tumors, ovarian cancer has the highest mortality rate of all gynecologic malignancies. Since the early symptoms of ovarian cancer are obscure and secretly, 60-70 % of patients present with already advanced disease, requiring major surgery and intensive and often complex additional therapies. The development of metastasis is [...]
Chapter I Expression and clinical significance of apoptosis associated proteins Bcl-2 in CholangiocarcinomaOBJECTIVE: To study the expression of apoptosis-associated protein Bcl-2 in normal bile duct and cholangiocarcinoma. To analyze the relationship between the positive rate of Bcl-2 expression and the clinical pathological parameters in cholangiocacinoma, and between the positive rate of Bcl-2 expression and the [...]
Part 1 Expression and Clinical Significance of nuclear factor kappa B and urokinase-type plasminogen activator in Human Transitional Cell Carcinoma of BladderObject Activation of transcription factor nuclear factor kappa B(NF-κB) has been showen to be an important original stage in malignant tumor evolution. NF-κB family proteins has been deemed to be involved to proliferation, angiogenesis, [...]
Objective To explore the effect of oligodeoxynucleotides (ODN A151) containing TTAGGG motifs on the cytokines secreted by splenetic lymphocytes of mice.Methods CD4+ T cells were isolated from spleen of C57BL/6J mice by magnetic-activated cell sorting (MACS), then simulated with anti-CD3 and anti-CD28, with or without 1, 5, 10μM ODN A151 and 10μM ODN 1612 for [...]
[Objective] To observe the changes of the proportion of CD4+CD25+ regulatory T cells and the levels of TGF-βand IFN-γin the peripheral blood of NSCLC patients and to study the influencing factors related to the changes.[Methods] A total of 30 NSCLC patients diagnosed pathologically without another treatments except for the operation were involved in the study. [...]
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