Objective:To explore the effects and mechanism of atrovastatin on expression of the NF-κB on retionpathy of diabetic rats.Methods:A total of 42 male SD rats were randomly taken out 28 to make diabetes model by induced injection of 65mg streptozotocin (STZ)into enterocoelia,the rest was normal control group.After the model maded, atrovastatin(2mg/kg/d) were given the treated group,and [...]
Nuclear factor-KB (NF-кB) is a family of transcription factors that share homology to the retroviral oncoprotein v-Rel. Abnormal levels of constitutively activated NF-кB have been detected in hematopoietic cancers including acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), Hodgkin’s lymphoma, and in various solid tumors (1-4). The active form of NF-кB is known to have [...]
The Change of Exhausted Exercise on the Expression of NF-kappaB、 BDNF in Hippocampus Nucleus in Rats
Objective:To observe the expression of NF-κB, BDNF in different times after 6 week exhausted swimming exercise . At the same time to investigate the mechanism of the injury and repair after exhausted swimming exercise in central nervous system .Methods: seventy healthy SD rats were randomly divided into control group(n=10) and exhausted swimming group(n=60).The fresh cerebral [...]
Aim:To evaluate in vivo anti-hepatoma effect of arenobufagin and explore probable molecular mechanisms of arenobufagin-induced apoptosis in doxorubicin-sensitive and -resistant human hepatoma cells (HepG2 and HepG2/ADM), and further study inhibitory effect of arenobufagin on the invasion and migration of HepG2 cells. Methods:S180 sarcoma and H22 hepatoma animal model in KM mice, together with orthotopic transplantation [...]
To study the protective effects of extract of dandelion on acute lung injury ( ALI) induced by lipopolysaccharide (LPS) and the molecular mechanism of protection in mice, to provide base for clinical prevention and treatment of acute pneumonia and lay the foundation for further development and utilization of dandelion as a gateway drug. First, aqueous [...]
Objective:To explore the mechanism of cryptotanshinone (CTN) and salidroside (SDS) against LPS-induced inflammation.Methods:RAW 264.7 cells were pretreated with various concentrations of CTN or SDS for 1 h and then stimulated with 1μg/ml LPS for 30 min or 24 h.Results:LPS significantly increased the levels of NO, phosphorylated TAK and the expression of iNOS, COX-2. CTN inhibited [...]
ObjectiveTo observe the Expressions of peroxisome proliferator-activator receptorγ(PPARγ)and nuclear factor-κB (NF-κB) and tumor necrosis factor-α(TNF-α) in rat kidneys with chronic renal ischemic model,dicuss the relationship in PPAγ、NF-κB、TNF-αand their affect on chronic ischemic renal disease (CIRD).MethodsEstablish animal models of chronic ischemic renal disease by unilateral partial ligation of the renal artery.Sprague-Dawley(SD) rats are randomly divided into [...]
Background Epidemiological and genetic data revealed that chronic inflammation could promote tumorigenesis. Tumor-associated macrophages (TAM) was major regulators between inflammation and cancer. TAM which was created in the tumor microenvironment displayed the function to promote tumorigenesis. Nuclear factor kB (NF-kB) was a key connection between inflammation and cancer. Lung cancer induced by coal tar was [...]
Objective:To illustrate the neuroprotective effect of gamma globulin on cerebral ischemia-reperfusion injury in rats and to explore the possible mechanism.Methods:90 adult Wistar rats with masculinity,weighing 250-280g,were randomly divided into 3 groups:sham-operation[sham-operation combined with normal saline (NS)];experimental control group [operation combined with normal saline (NS)] and experimental group [operation combined with gamma globulin]; rat models of [...]
Objective:1.To observe the changes of the myocardial heat shock protein 70(HSP70) and nuclear factor-kappa B(NF-κB) in immature myocardial hypoxia ischemia injury by establishing the model of neonatal rats with normobaric asphyxia.2.To investigate the effect of Xinmailong on the anti-immature myocardial hypoxia ischemia injury and its mechanism through observing the changes of the myocardial HSP70 and [...]
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