As major neurotransmitters, catecholamines (including dopamine, epinephrine, norepinephrine and serotonin) play important roles in the function of brain and nerve signal transduction, They are directly involved in a variety of biological activities, such as analgesics, physical movement, mental activity, sleep, awakening, stress, etc. The levels of catecholamines in the body are closely related to human [...]
Objective:To approach the mechanism of glutamate (Glu) and glutamine (Gln) and gamma-aminobutyric acid (GABA) in mediating the antagonism of taurine (Tau) to injury of rats’cerebral ganglion nerve cells induced by manganese (Mn), we applied the primary culture method on cerebral ganglion nerve cells of baby rats.Methods:We took the nerve cells of cerebral ganglion from SPF [...]
QO-58, a new compound screened by Hebei Medical University, shows a good activity to enhance the potassium channel KCNQ2/3 currents in vitro experiments. KCNQ2/3 channel as a major composition of M currents is mainly distributed to nervous system. The channel can be activated near the threshold potential, and determining the excitability of neuron, that is [...]
Background and Objective:In recent years, drinking is a necessary part of life, the necrosis of femoral head cases became more and more because of alcoholism. But the precise etiopathogenesis of ONFH remains unclear. Pervious studies showed that there is BMSCs exist in the bone marrow which could differentiate into osteoblast, chondroblast, adipocyte or neurocyte. Studies [...]
QO-58, a new compound screened by Hebei Medical University, shows a good activity to enhance the potassium channel KCNQ2/3 currents in vitro experiments. KCNQ2/3 channel as a major composition of M currents is mainly distributed to nervous system. The channel can be activated near the threshold potential, and determining the excitability of neuron, that is [...]
Background and Objective:In recent years, drinking is a necessary part of life, the necrosis of femoral head cases became more and more because of alcoholism. But the precise etiopathogenesis of ONFH remains unclear. Pervious studies showed that there is BMSCs exist in the bone marrow which could differentiate into osteoblast, chondroblast, adipocyte or neurocyte. Studies [...]
Background and Objective:The steroid-induced necrosis of femoral head cases became more and more because of the widespread using of steroid in the clinical. But the accurate etiopathogenesis of ONFH still unclear. Pervious studies showed that there is BMSCs exist in the bone marrow which could differentiate into osteoblast, adipocyte, chondroblast, or neurocyte, et al. Studies [...]
Hippocampus plays an important role in study and memory, which is the functions of the brain, and several parts of the brain contribute to this function. Hippocampus is located in the inferior horn and inside wall of lateral ventricle, and connects to the dentate gyrus, shaped like the letter C on the coronal plane. Hippocampus [...]
Purpose:Through clinical observation and animal research, to explore the effect of interference and the regulation mechanism of acupuncture on irritable bowel syndrome and the CGRP,5HT, NPY of the brain-gut interaction model.Methods:It’s a single-blind randomized controlled clinical trial, and 117 patients with IBS were randomly divided into two groups. Treatment group with 56 patients were accepted [...]
Objective: To evaluate the clinic efficacy of Qiangzhisan in patients with Tourette’s Syndrome (TS),and to explore the mechanism.Methods:Clinical studies:According to the diagnostic criteria, 66 TS patients were randomly divided into two groups. The treatment group (n=33) received Yishenqiangzhi therapy, and the control group (n=33) received oral haloperidol therapy,observe children symptoms, signs and EEG. Experimental studies: [...]
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