Objective: To study the expression and the effect of Foxj1in the central nervoussystem in Traumatic Brain Injury.Methods: Healthy male Sprague-Dawley rats were randomly divided into3groups:operation group, sham operation group, and control group. The brain stab-injury models ofrat were performed. Western blot and immunohistochemistry analysis were showed toinvestigate the expression of Foxj1at various times after injury. [...]
Adult hippocampal neurogenesis is involved in the physiology and pathogenesis of various diseases and to develop dugs that enhance adult neurogenesis will be beneficial for the treatment of neuropsychological diseases. Major depression is a common mental disorder its incidence increased year by year. Depression will be the second leading illness in the world by2020as projected [...]
ObjectiveA rat model mimicking neonatal hypoxic was established to investigate the effects of transient hypoxia in brain on the expression level of NeuroD, apoptosis and neurogensis. Importantly, this study may result in novel interventions for management of hypoxic-ischemic encephalopathy.Methods1. The model was established as previously described by Grojean. Briefly, newborn rats were transiently exposed to [...]
Chapter one:Neurons and astrocytes differentiated from mouse embryonic stem cells induced by IsobavachinObjective:To evaluate the inductive effects of isobavachin (IBA) on the directed differentiation of mouse embryonic stem(ES) cells into neuronal cells in vitro and study the mechanism. Methods:The hanging drop method was employed for embryonic body formation to mimic embryo development in vivo. The [...]
Background:Vascular dementia (VaD) is one of the major types of senile dementia, also the most common cause of dementia, which brought eavy burden of financial and spiritual to the family and society. VaD has become an important research focus in elderly medical field. Recently, vascular cognitive impairment(VCI) has been paid more and more attention by [...]
Epilepsy is one of the most common neurological disorders characterized by recurrent and unpredictable seizures. It is estimated about 50 million people suffered from epilepsy worldwide. The currently available AEDs are mainly symptomatic, which block seizures but do not affect the underlying pathology or the progression of the disorder. Therefore, prevention of epileptogenesis has become [...]
Ndrg2 is a member of the N-myc downstream-regulated gene(NDRG) family. Thus far, the full-length cDNA of Ndrg2 encodes 2 different protein variants of 371 aa(41kDa) and 357aa, respectively. It is a cytoplasmic protein involved in cell differentiation, development and apoptosis (Yao et al., 2008) (Choi et al., 2003). At embryonic day 9.5(E9.5), Ndrg2 mRNA was [...]
Neonatal hypoxic-ischemic brain damage (hypoxia-ischemic brain damage, HIBD) is the most common causes to neonatal deaths and the neonatal nervous system damage.According to statistics, there are about 1,2 HIBD neonatal cases caused by perinatal asphyxia in 1000 cases.There are about 15～20% children with HIBD will dead in the neonatal period, approximately 25% of the surviving [...]
Background and objectiveIt’s well known that depression disorder has become to a common clinical disease. Thehypothesis of pathophysiology mechanism about depression now consist of monoamineneurotransmitter hypothesis,disfunction of neuroendocrine system and neural plasticity.Theneurogenic hypothesis postulates that a reduced production of new neurons in the hippocampusrelates to the pathogenesis of depression and that successful antidepression treatment requires [...]
Objective:As a technology carrier, RNAi was used to explore the feasibility and effectiveness of RNAi-mediated Hes1 gene downregulation in vivo, further to demonstrate its role for adult neurogenesis and repair of neurological function after TBI.Through this study, we preliminarily detect the possible mechanism that Hesl gene regulated adult neurogenesis, to find the approach that can [...]
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