Objective:To investigate the clinical characteristics,treatment and prognostic factors of postoperative recurrent-metastatic gastrointestinal stromal tumor (GIST). Methods:Retrospective analysis of Dalian Medical University from March 1999 to March 2008 for the first time 123 cases of surgical treatment of recurrent and metastatic GIST patients the clinical features of 85 patients, treatment and assessment of prognosis.Results: 85 cases […]

BACKGROUND AND PURPOSES:Bone, as well as liver and lung, is one of the most preferential metastatic target sites for cancer including prostate, breast, and lung cancers. Up to 70% of prostate or breast and approximately 15-30% carcinoma of lung and other solid tumor will develop bone metastasis. Once the cancer occur bone metastasis, the cancers […]

Background:Bone is one of the most common sites of metastatic tumor. The Incidence of bone metastatic tumors in the body was No.3, only after lung metastases and liver metastases. Prostate cancer, breast cancer, lung cancer, kidney cancer and thyroid cancer are common tumors which prone to metastasis to bone. Bone metastases means lower survival rate, […]

Objective:To explore LOXmRNA expression in breast cancer cell lines which have different invasive/metastatic potential. Observing the tumour growth and metastasis in breast cancer model. Compare the LOX, MMP-2, MMP-9 and HIF-1αprotein expression in breast cancer model.Analyze the correlation between LOX and MMP-2, MMP-9, HIF-1α.Detect the LOX, MMP-2, MMP-9 protein in breast cancer tissues and analyze […]

Objective To explore the expression of N-myc downstream regulated gene-1 (NDRG1) in nasopharyngeal carcinomas (NPC) and the relationship with clinicopathological parameters and prognosis.Methods NDRG1 was detected at its protein level by immunohistochemistry (IHC, SP method) in formalin-fixed and paraffin-embedded sections with a total of 100 specimens including 80 nasopharyngeal carcinoma and 20 chronic nasopharyngitis tissues. […]

Objective : The recent developments of glycoproteomics and glycomics technologies allow us to analyze the serum glycoproteins from the patients bearing hepatocellular carcinoma (HCC) with different degree of malignancy.By the dynamic changes of protein and sugar levels we explored the molecular markers and discuss the characteristics of metastatic HCC.Background:Proteomics technologies analyze the structure and function […]

Objective: To investigate the application of spectral CT imaging in different lymphnode lesions,especially lymph node metastases, through the analysis about spectral featuresof lymph node paraffin-embedded tissues (PETs) and metastatic or non-metastatic lymphnodes of lung carcinoma.Part One the study of spectral CT imaging of lymph node paraffin-embedded tissues (PETs)Materials And Methods: Lymph node paraffin-embedded tissues (PETs) […]

Objective:To summarize the clinical and pathological characteristics of gastrointestinal stromal tumor with liver metastases and to explore its principles of diagnosis and treatment.Methods:We retrospectively analyzed the clinical data of20patients with liver metastases who had a completely case history in our hospital from October2009to October2010.Results:Among20patients, the median age was55.5(17-80).13cases were confirmed by pathological examination and7patients were […]

Objective:To investigate the effect of resection for thoracic and lumbar metastatictumors and the relationship between the treatment result and influential factors.Methods: From September2003to August2010,there were40cases who underwentsurgical treatment because of thoracic and lumbar metastatic tumors in the department oforthopedics of the Fourth Affiliated Hospital of SuZhou University. We adoptedquestionnaire investigating way, telephone and out-patient callback […]

Objective Research the expressions of OPN and VEGF in colorectal carcinoma, adenoma and normal mucosal tissues and their relationship with clinicopathological factor.Methods In this experiment,40samples of colorectal cancer,20samples of colorectal adenoma and40samples of normal mucosa specimens were studied. To detect the expression of OPN and VEGF in specimens by S–P immunohistochemical method.Results①ne positive expression rates […]