Effect of Candesartan on Expression of VEGF and MCP-1 in Rat Retina with Diabetetes Mellitus

26. June 2012 · Comments Off · Categories: Ophthalmology · Tags: , , ,

ObjectiveTo observe the effects of candesartan on the expression of vascular endothelial growth factor (VEGF) and monocyte chemotactic protein (MCP-1) in the retinopathy of diabetic rats.MethodsDiabetes models were established in 48 SD rats by the injection of streptozotocinum(STZ) 40 mg·kg-1 to elevate the blood glucose to 16.7mmol·L-1 on the third day. Then successful model rats [...]