Part1Functional Genetic Variations in Interleukin-23Receptor andSusceptibility to Nasopharyngeal Carcinoma in Chinese PopulationInterleukin-23receptor (IL-23R) is a key element in the T-helper17(Th17)cell-mediated inflammatory process, which plays an important role in the pathogenesisof cancer. This study examined whether genetic polymorphisms in IL-23R areassociated with nasopharyngeal carcinoma (NPC) susceptibility. A total of1,590cancerpatients and2,136control subjects from eastern and southern Chinese [...]
Part I affect of heterozygous variations of FOXP3on breast cancerrisk via skewed X-chromosome inactivationAs a transcription factor, FOXP3is not only a well known hallmark of immunesuppressive T regulatory cells (Tregs), but also an X-linked breast cancer suppressorgene expressed in tumor cell itself. Tregs are the major cell type mediating tumorimmunity suppression regulated by FOXP3expression. However, [...]
Enteroviruses (EVs) are the most important cause of aseptic meningitis in children, which is the most commonly encountered serious illness. Echovirus9(ECHO9) is one of the most common EV genotypes detected from patients with aseptic meningitis, often appearing in the form of an epidemic or endemic.The objective of this study is to carry out a comprehensive [...]
The study of human rhinoviruses made significant progress in the late 20th century; several important events had been identified in viral life cycle which laid foundation to the further research of the biological characteristics and pathogenic mechanisms of human rhinoviruses. Human rhinoviruses, the most frequently isolated virus, are not only acute, chronic respiratory tract pathogens [...]
The study of human rhinoviruses made significant progress in the late 20th century; several important events had been identified in viral life cycle which laid foundation to the further research of the biological characteristics and pathogenic mechanisms of human rhinoviruses. Human rhinoviruses, the most frequently isolated virus, are not only acute, chronic respiratory tract pathogens [...]
The study of human rhinoviruses made significant progress in the late 20th century; several important events had been identified in viral life cycle which laid foundation to the further research of the biological characteristics and pathogenic mechanisms of human rhinoviruses. Human rhinoviruses, the most frequently isolated virus, are not only acute, chronic respiratory tract pathogens [...]
The study of human rhinoviruses made significant progress in the late 20th century; several important events had been identified in viral life cycle which laid foundation to the further research of the biological characteristics and pathogenic mechanisms of human rhinoviruses. Human rhinoviruses, the most frequently isolated virus, are not only acute, chronic respiratory tract pathogens [...]
The study of human rhinoviruses made significant progress in the late 20th century; several important events had been identified in viral life cycle which laid foundation to the further research of the biological characteristics and pathogenic mechanisms of human rhinoviruses. Human rhinoviruses, the most frequently isolated virus, are not only acute, chronic respiratory tract pathogens [...]
Background and ObjectiveNoV was first isolated from the patient feces in an outbreak of acute diarrhea in 1968, which occured in Norwalk City, the United States. And it was named as Norwalk virus according to the discovering place. Because the virus cannot be carried on cell culture, cannot build animal models, also did not have [...]
[Background]Human enteroviruses, small RNA viruses in the family of Picornaviridae, based on genetic relationships between the virus strains, HEV were grouped into four species designed Human enteroviruses A, B, C and D. Aseptic Meningitis mostly associated with kinds of viruses’infection. The yearly incidences of AM are 11 to 27 per 100,000 population in the word,85% [...]
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