ObjectiveVascular endothelial growth factor（VEGF）has been implicated as a critical molecular signalin tumour development,by promoting angiogenesis and possibly by exerting autocrine functionsin tumour cells.Some studies showed that VEGF was over expressed in hepatocarcinoma. Howto inhibit effectively the expression of VEGF is the emphasis of tmuor treatment.MicroRNA（miRNA） is a small non-coding RNA that cantains 21 to 23 [...]
Background:MicroRNAs(miRNAs) are an abundant class of 20-22 nucleotide small non-coding,evolutionarily conserved RNA molecules that negatively regulate gene expression through sequence-specific translational repression and/or degradation of cognate mRNA.MicroRNAs have been implicated in control of many fundamental cellular and physiological processes.Mounting evidence indicates that their aberrant expression might be involved in human cancers,and they might be useful [...]
BackgroundOxidative stress and high levels of reactive oxygen species (ROS) are associated with the drug-and noise-induced, and age-related hearing injury and loss. Cisplatin, aminoglycosides and continual noise can promote high levels of ROS production in hair cells. Furthermore, increased levels of antioxidants support hair cell survival and function. Previous studies have revealed that high levels [...]
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