Objective: Given the present studies, the association of the two ERCC polymorphisms, Asp312Asn and Lys751Gln, with lung cancer risk remains controversial and inconclusive. To better evaluate the potential role of these two ERCC2 polymorphisms and their interaction with tobacco smoking in lung cancer susceptibility presented in diverse populations, we have conducted this systemic review and [...]
Objective:To investigate the effect of the cisplatin on the resistance cells of Lewis lung cancer xenografts in mice, to analyze the expression of P-gp and growth inhibition rate of the xenografts,and by approach the relation of the the expression of P-gp and cisplatin.Methods:The C57BL/6 mice were used to the experimental animals.The resistance cells of Lewis [...]
ObjectiveLung cancer is the leading cause of cancer-related deaths for both men and women worldwide. Tobacco intake is the main risk factor associated with lung cancer. Nicotinic acetylcholine receptor signaling pathway is the research focus of lung cancer in recent years.Genome-wide association analysis showed that CHRNA5 gene encoding a5-nicotinic acetylcholine receptor (a5-nAchR) is particularly relevant [...]
Background & Objective:Lung cancer is one of the most common malignant tumors, whose morbidity and mortality are increasing gradually, and become the main cause of death in most of the countries. In recent years, with the improvement of knowledge about lung cancer and development of moleculary biology, people have done a large number of basic [...]
PurposePreliminary study on peripheral four distinct CD4~+T-cell subsets including Th1, Th2, Th17 and Treg in healthy individual. And preliminary study on the clinical significance and dynamic change of CD4~+T-cell subsets in lung cancer patients before and after the Radiofrequency ablation(RFA) therapy.Materials and MethodThe peripheral heparinized blood samples were obtained from30 healthy controls and 6 patients [...]
Objective:To investigate the relationship between RAD51 G135C polymorphism, Jung cancer risk,pathological characteristic, and p53 mutation in lung cancer.Methods:A total of 80 lung cancer cases and 40 controls with lung non-neoplastic diseases were collected. We analyzed the genotypes of RAD51 (135GC) by PCR-RFLP and detected the p53 mutation of 80 lung cancer cases by imnunohistochemistry,then determined [...]
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