Objective:To investigate the change of the content of dopamine （DA） and the DA D1 receptor and D2 receptor immunoactivities in hippocampus during convulsion induced by lidocaine in rats. And using the DA D1 receptor agonist SKF38393 and D2 receptor agonist pergolide to explore the potential mechanism of DA receptors in the process of convulsion.Methods:Twenty-four male [...]
Objectives:To investigate the effects of Preoperative epidural ropivacaine and sufentanil on postoperative pain and plasma IL-6、TNF-αconcentration,so as to conclude the clinical effect of pre-emptive analgesia.Methods:31 patients suffering uterine cervix cancer（stageⅠb toⅡa,from 30 to 55 years old,ASAⅠ-Ⅱ）undergoing total hysterectomy and extensive lymph node dissection were randomly divided into pre-emptive group（group A,n=16）and control group（group B,n=15）.An epidural catheter [...]
The toxicity of local anesthetics happens when the concentration of local anesthetic in blood exceeds the tolerance of body, which mainly include the central nervous system toxicity and cardiotoxicity. The reaction of local anesthetics and their mechanism were described in this review. the prevention, treatment and announcements were also included .
Background & objectivePain is a major problem of human health problems. The prevalence rate of pain is about 21.5% around the world. The harmful and negative effects of pain are incalculable, such as it can cause different degrees of fear, panic, anxiety, grief and other undesirable emotions, system dysfunction, lower immunity, leading to various complications, [...]
Background: Lipid emulsion (LE) therapy can rapidly restore circulation after local anesthetic–induced cardiovascular collapse. Experimental models of local anesthetic toxicity have shown accelerated return of spontaneous cardiac function after lipid infusion in both intact animals and the isolated heart. Several case reports have extended these findings to the clinical setting, where patients in cardiac arrest [...]
The central nervous system (brain and spinal cord) could be damaged by both ischemia/reperfusion injury and anesthetics during the perioperative period. The brain and spinal cord ischemia can be caused by surgical procedures such as intracranial arterial-venous malformations, thoracic and abdominal aortic aneurysm surgery. And the toxicities of anesthetics such as local anesthetics can also [...]
BackgroundNeuraxon anesthesia is becoming more and more popular in clinical practice. The worst complication associated with the administration of local anesthetics is local anesthetic systemic toxicity (LAST). These agents always have the profound and potentially lethal effect on cardiac conduction and function. LipidRescueTM resuscitation refers to the use of an intravascular infusion of a lipid [...]