Colorectal cancer is one of the most common gastrointestinal cancer in the world. Liver is the most common organ of colorectal cancer metastasis, and ultimately up to50%of colorectal caner patients will be died of liver metastasis. Hematogenous metastasis is the main ways of liver metastases from colorectal cancer due to anatomical location. In the early [...]
20. December 2012 · Comments Off · Categories: Oncology · Tags: animal models, Colorectal cancer, Liver metastasis, location
17. December 2012 · Comments Off · Categories: Oncology · Tags: Liver metastasis, Percutaneous ethanol injection, radiofrequency ablation
BackgroundThe liver is the largest solid organ of the body and is rich in blood. Many of malignant tumors of other organs can metastasize to liver in different ways, such as lymph, blood, or directly invasion of the liver to the formation of metastatic liver cancer, also known as secondary liver cancer. Wong Ka Si [...]
14. December 2012 · Comments Off · Categories: Pharmacy · Tags: apoptosis, Colon, Endostar, Liver metastasis
Objective:To investigate the recombinant human endostatin combined with XELOX on the inhibition of growth and liver metastasis of mouse colon carcinoma, and to explore the influence of recombinant human endostatin to efficacy of traditional chemotherapy,and also to provide experimental basis and reference for follow-up research and clinical application.Methods:In this study, we establish colon cancer metastasis [...]
18. June 2012 · Comments Off · Categories: Medical edu · Tags: animal, Colorectal cancer, CT26, disease models, Liver metastasis
Objective:To establish and improve an animal model of mice colon cell cancer liver metastases in BALB/c mice, and provides stable platform for the study of liver metastasis mechanism and biological behaviour. Methods:CT26 murine colorectal cancer cell line selected by subcutaneous transfer made after the 3rd generation cell suspension and the CT26 cell suspension were inoculated [...]
15. June 2012 · Comments Off · Categories: Oncology · Tags: animal experiments, Biological active peptide, Colorectal cancer (carcinoma of large intestine), CT26 cells, Liver metastasis, RGDS
Objective: Upon the inhibition effect that RGDS (comes from fiber adhesion protein fN, short chain repeat sequence biological active peptide, arginine- glycine– aspartic-acid serine (RGDS) sequence )on mice liver metastases after those spleens were inoculated with CT26 cells , discusses the inhibition mechanism, and the application prospect of prospects do a preliminary study.Methods: First, established [...]
05. June 2012 · Comments Off · Categories: Oncology · Tags: cetuximab, Chemotherapy, Liver metastasis, Nasopharyngeal carcinoma, Nedaplatin, Prognostic factor, tegafur
BackgroundNasopharyngeal carcinoma(NPC)is a malignant tumor with remarkable epidemiological,pathological and anatomical features. Southern China, Southeast Asian, the Middle East, North Africa, et al are areas of high incidence. Radiotherapy (RT) is is an essential component of curative-intent treatment for NPC patients. Radiotherapy alone is the most important choice for early stages; the 5-yesar survival rate can [...]
23. May 2012 · Comments Off · Categories: Oncology · Tags: CDKL1, Colorectal cancer, CUGBP1, immunohistochemisty, Liver metastasis, SCIN, SLC16A7
Objective:Using immunohistochemical techniques detected the expression of SCIN, CDKL1, CUGBP1 and SLC16A7 in colorectal cancer primary lesion. Furthermore, study the relationship between SCIN, CDKL1, CUGBP1, SLC16A7 with clinicopathological characters and prognosis of colorectal cancer liver metastasis. Method:From 2001 to 2009,300 patients who underwent colorectal cancer surgery in the Department of General Surgery of Zhongshan Hospital [...]
23. May 2012 · Comments Off · Categories: Oncology · Tags: Colon cancer, Liver metastasis, phosphatase and tensin homolog
Objective:The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling, we investigated PTEN expression in colon cancer and colon cancer liver metastases, in order to evaluate the correlation between PTEN expression and clinicopathological characteristics of colon cancer patients with and without liver metastases.Methods:Forty-two primary colon cancer and corresponding liver [...]
20. May 2012 · Comments Off · Categories: Oncology · Tags: animal models, Colon cancer, Galectin-3, Liver metastasis, Low-Molecular-Weight Citrus Pectin, oxaliplatin
Background and objective:Galectin-3, aβ-galactoside-binding protein, has been involved in various physiological and pathological processes, such as cell growth, proliferation, differentiation, apoptosis, cell adhesion, angiogenesis, tumor progression and metastasis. The aim of this study was to investigate the effects of Low-Molecular-Weight Citrus Pectin (LCP),a galectin-3 inhibitor, combining with Oxaliplatin on the growth and liver metastasis of [...]
18. April 2012 · Comments Off · Categories: Oncology · Tags: 5-AIQ, colon adenocarcinoma, Liver metastasis, NF-κB p65, PARP
Objective: The aim is to investigate the changes of liver metastasis of mouse colon adenocarcinoma CT26 cell line by Poly (ADP-ribose) polymerase inhibition in vivo,and how it plays its role.Methods: 5-aminoisoquinolinone served as the inhibitor of PARP.The Balb/c mice syngenic colon adenocarcinoma CT26 cell line liver metastasis model was used. Various concentrations of 5-AIQ treated [...]
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