Objective:To establish and improve an animal model of mice colon cell cancer liver metastases in BALB/c mice, and provides stable platform for the study of liver metastasis mechanism and biological behaviour. Methods:CT26 murine colorectal cancer cell line selected by subcutaneous transfer made after the 3rd generation cell suspension and the CT26 cell suspension were inoculated […]

BackgroundNasopharyngeal carcinoma(NPC)is a malignant tumor with remarkable epidemiological,pathological and anatomical features. Southern China, Southeast Asian, the Middle East, North Africa, et al are areas of high incidence. Radiotherapy (RT) is is an essential component of curative-intent treatment for NPC patients. Radiotherapy alone is the most important choice for early stages; the 5-yesar survival rate can […]

Objective:According to the important role in the signal transduction in the metastasisingof tumor of GHR,through setting up a growth hormone receptor plasmi and establishing the liver metastasis model in BALB/c mice of human colon cancer cells SW480, and combining 5-fluorouracil to research of liver metastasis of colon carcinoma on /BALB/c mice by small interfering RNA […]

Background and objective:Galectin-3, aβ-galactoside-binding protein, has been involved in various physiological and pathological processes, such as cell growth, proliferation, differentiation, apoptosis, cell adhesion, angiogenesis, tumor progression and metastasis. The aim of this study was to investigate the effects of Low-Molecular-Weight Citrus Pectin (LCP),a galectin-3 inhibitor, combining with Oxaliplatin on the growth and liver metastasis of […]

Objective:Using immunohistochemical techniques detected the expression of SCIN, CDKL1, CUGBP1 and SLC16A7 in colorectal cancer primary lesion. Furthermore, study the relationship between SCIN, CDKL1, CUGBP1, SLC16A7 with clinicopathological characters and prognosis of colorectal cancer liver metastasis. Method:From 2001 to 2009,300 patients who underwent colorectal cancer surgery in the Department of General Surgery of Zhongshan Hospital […]

Objective:The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling, we investigated PTEN expression in colon cancer and colon cancer liver metastases, in order to evaluate the correlation between PTEN expression and clinicopathological characteristics of colon cancer patients with and without liver metastases.Methods:Forty-two primary colon cancer and corresponding liver […]

As the population growth and the arrival of aging society, the incidence of cancer continues to rise at global, particularly in developing countries. Colorectal cancer as one of the common digestive tumor , which the number of new cases is the third at male and the second at female, the deaths in the forefront of […]

Background and Objectives:It is currently known that regulatory T cells (Tregs) play an important role in transplantation and tumor immunity. Due to the lack of suitable animal models, the exact impact of regulatory T cells on liver tumors after liver transplantation (LT) is not known. Our study revealed the impact of Treg-mediated immune micro-environment changes […]

Abstract:Colorectal cancer is a common malignancy of gastrointestinaltract,and the incidence of colorectal cancer is becoming higher and higher.Atpresent had the trend,that the incidence of colon cancer is higher than theincidenceof rectal cancer.Early colorectal cancer often has no obvious symptoms,when itis discovered the Pathologic stage is late.Diagnosis and differential diagnosis ofthe cancer mainly relies on symptoms,signs,Tumor […]

Colorectal cancer is one of the most common gastrointestinal cancer in the world. Liver is the most common organ of colorectal cancer metastasis, and ultimately up to50%of colorectal caner patients will be died of liver metastasis. Hematogenous metastasis is the main ways of liver metastases from colorectal cancer due to anatomical location. In the early […]