Objective: To observe the pro-phagocytic signal calreticulin (CRT) and anti-phagocytic signal CD47expression in laryngeal squamous cell carcinoma (LSCC),to discuss the role of CRT and CD47in the occurrence and development of LSCCand the relevance with T lymphocytes infiltration.Methods: The expression of CRT and CD47mRNA in42cases of LSCC and18cases of peri-cancer tissues was detected by reverse transcription-polymerase [...]
Objective: Laryngeal squamous carcinoma is one of the most common malignant neoplasms in the head and neck region, accounting for 13.9% of all malignant neoplasms in the head and neck region. Investigation about the mechanisms of the carcinogenesis, growth and metastasis of laryngocarcinoma are warm spots in head and neck cancer research. This is also [...]
Expression of Caveolin-1 and Its Correlation with HPV Infection in Laryngeal Squamous Cell Carcinoma
Background:Among these was 50 to100nm inaginations of the plasma membrane referred to as either caveolae intracellulare, due to their cave-like appearance, or plasmalemmal vesicles. The molecular nature of caveolae could be explored following the identification of its signature protein, caveolin. Caveolae being implicated and demonstrated to be important in a variety of cellular functions including [...]
ObjectiveTo explore CNO supraglottic carcinoma therapeutic method, clinical effect and prognosis research.MethodDivide the patients of 147 cases prognosis research supraglottic carcinoma with surgical treatment into groups (operation group and observation group) and have clinical analysis. The clinical stage is classified according to UICC 2002 staging system. It includes stage I 13 cases, stageⅡ80 cases, stageⅠ11 [...]
Objective: To compare and evaluate the oncological and functional outcomes between reserving thyroid partial laryngectomy and other traditional partial laryngectomy for the treatment of stage T2-3 glottic laryngeal carcinoma.Method:One hundred and twenty eight patients treated from 1999 to 2007 were selected from all glottic carcinoma patients with stage T2-3 in the first affiliated hospital,Dalian Medical [...]
ObjectiveTo explore the effect of TGF-β1/Smad4 signaling system in Laryngeal squamous cell carcinoma by investigating the expression of Transforming growth factor-β1(TGF-β1), Transforming growth factor-βreceptorII (TβRII) and Smad4 in human laryngeal squamous cell carcinoma(LSCC) and normal laryngeal mucosa. It would provide the basis for judging to stage of LSCC’s invasion and predicting the prognosis, finding new [...]
ObjectiveTo ascertain the relationship between polymorphisms and laryngeal squamous cell carcinoma(LSCC)occurrence and development, PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) was used to detected the polymorphisms of Pinl (peptidyl-prolyl cis/trans isomerase 1)in a hospital-based case-control study of patients with LSCC and cancer-free control subjects. Three selected Pinl polymorphisms (rs2233678、rs2233679and rs2287838) were genotyped. The genotype frequencies [...]
Objective:To study the changes of proteomic spectra in serum from patients with laryngeal carcinoma in order to find the tumor markers which might predict the progression, metastasia and prognosis of the tumor and investigate their expression in preoperative and postoperative serum and provid a trend for curing and preventing the laryngeal cancer in the molecular [...]
Objective To investigate the roles of E-cadherin and alpha,beta-catenin play in the carcinogenesis and progression of laryngeal carcinoma.Method Immunohistochemistry staining(PV6000 two steps method) was used to detect E-cadherin and alpha,beta-catenin proteins expression in laryngeal carcinomas,normal epithelia around tumors and laryngeal papilloma.Results(1)The abnormal rates of expression rates of E-cadherin and alpha,beta-catenin in 60 laryngeal carcinomas were [...]
Objective To assess and discuss the difference of quality of life(QOL) between laryngeal cancer patients after laryngectomy with total and partial laryngectomy.Study the difference of quality of life of different modus operations;Analyze the related factors of postlaryngectomy QOL and search the method to improve QOL;Assess the feasibility of applying the FACT- H & N questionnaire [...]
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