Objective1. To investigate the expression of HPV,HER2,EGFR and Ki67 in the cervical squamousintraepithelial canceration course,analyze the correlation between the expression and clinicalpathological parameters, and analyze the correlation of the four gene.2.Through the comparison of HER2 protein/gene status detected byimmunohistochemistry(IHC), Fluorescent in-situ hybridization(CISH), to explore the clinicalsignificance of IHC and FISH on detecting HER2 gene status.Methods1. [...]
Aim:To investigate the expression of Bmi-1, P16and Ki67in Choroidal Melanoma. To determine the relationship between Bmi-1and malignancy of choroidal melanoma, and to explore the mechanism of Bmi-1in choroidal melanoma, the correlation analysis between Bmi-1/Ki67and Bmi-1/P16was respectively studied.Methods:The expression of Bmi-1, P16and Ki67in Choroidal Melanoma and nevi were detected by immunohistochemistry, and the correlations with clinicopathological [...]
Background and ObjectiveIn female malignancy, the incidence of endometrial cancer is increasing year by year, second only to cervical cancer, colorectal cancer and lung cancer, therefore, early diagnosis and treatment of endometrial cancer are extremely important. Activation of oncogenes, inactivation of tumor suppressor gene and cell cycle abnormalities play important roles in the development of [...]
Objective: Morphological changes of the mouse jejunum, ileum and colon,changes in the distribution and number of BrdU or Ki67immune response-positiveproliferative cells in the intestinal epithelium and that in β-catenin expression levelsin the intestinal villi and intestinal glands were observed after different doses of γ-rayirradiation, to understand the degree of intestinal injury and the proliferative status [...]
Objective To investigate the impact of intermittent hypoxic stimulation on rat glioma experimental model.Methods Methods:Surgical microscope and stereotaxic apparatus were applied to produce rat C6glioma model.64male Wistar rats were randomly divided into5groups:group A:the control group rat right caudate nuclear injection of lOμl of DMEM (Dulbecc’s modified eagle medium, in DMEM) medium, were not hypoxic stimulation [...]
Objective:.To detect the expression of P53, Ki67, MUC2, PCNA in chronic gastritis, dysplasia and cancer tissues by immunohistochemistry to analyze the differential expression and evaluate the clinical diagnostic value.Methods:We collected 108 samples in the People’s Hospital of Jiuquan City including 27 cases of gastric cancer,30 cases of chronic gastritis,32 cases of low-grade intraepithelial neoplasia and [...]
Objective: To explore the expression of Skp2 and Ki67 in cervical intraepithelial neoplasia and cervix carcinoma and its clinical significance.Methods: The expression of Skp2 and Ki67 were assessed by immunohistochemistry (EliVision) in cervical specimens, including 60 cases of cervix carcinoma and 30 cases of cervical intraepithelial neoplasia (CIN) , and 60 cases of normal cervical [...]
Objective:To investigate the expression of protein kinase C isoforms betaⅡ(PKCβⅡ),epidermal growth factor receptor(EGFR) and Ki67 in gastric carcinoma,explore their relationship with pathologic features,to know the biology behavioral trait of gastric carcinoma.Methods:Immunohistochemical technique(S-P) was used to detect the expre-ssion of PKCβⅡ,EGFR and Ki67 in 105 samples of gastric carcinoma and their adjacent normal gastric tissues, the [...]
Objective: To investigate the expression of MMP-2, VEGF, CD105 and Ki67 in human small cell lung cancer tissues, normal lung tissues and the correlation of the four indicators, and analyze the relationship between the biological characteristics and prognosis. It will provide theoretical basis for the clinical treatment and prognosis in SCLC.Methods: Immunohistochemistry SP method was [...]
Objective: Breast cancer is one of the most common woman malignant tumors. Around the world, there are about 1,200,000 women suffering from breast cancer and 50,000 women die from it each year. Now, the main treatment for breast cancer has become combined methods constituting of surgical removal and chemotherapy including target therapy instead of surgical [...]
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