Objective To investigate the effects of Sodium Demethylcantharidate Injection onadherence, invasion and metastasis and to investigate the related mechanism in humanhepatocarcinoma cell line HepG2.Methods The hepatocellular carcinoma HepG-2 cells were cultured，and divided into5 groups. namely control and different Sodium Demethylcantharidate Injection (0.5、1.0、2.0和4ug/ml)groups adherence ability, migration and invasion of HepG2cellinhibited by Sodium Demethylcantharidate Injection were assessed [...]
Trichinella spiralis is an intracellular parasitic nematode as both a larva and an adult can be found in the same host’s muscle and intestinal epithelial cell. The parasite can infect susceptible hosts and it can infect more than 150 kinds of animals. Trichinellosis caused by Trichinella spiralis is a major food-borne zoonosis. Following people or [...]
Background:Squamous cell carcinoma of the tongue was one of the most common malignant tumors in oral and maxillofacial tumors, which had the features of rapid growth, strong local invasion and higher lymphnode metastasis rate. Among the biological features, easier transfer to lymphnodes of neck area, especially, had an in important role on the prognosis of [...]
Objective:To discuss the effects of Ml and M2macrophages on the SGC-7901gastric tumor cells in vitro.Methods:Monocytes which were isolated from healthy volunteers peripheral blood by the MACS CD14Microbeads were cultured and induced into two subgroups:granulocyte macrophage colony stimulating factor(GM-CSF)used to obtain Ml macrophages,and macrophage colony stimulating factor(M-CSF)used to obtain M2macrophages.Then their phenotypes were identified by CD16and [...]
Lung cancer is the leading cause of cancer-related deaths worldwide andnonsmall cell lung carcinomas (NSCLC) account for approximately80%of lungcancer cases. Over the past decade, a number of new agents have been used to prolongsurvival and to improve life quality of NSCLC patients. Despite advances in surgeryand adjuvant therapy, most anticancer agents cause severe side effect [...]
Objectives1. To analyze the binding statues of ERC(N5) and human umbilical vein endothelial cells (HUVEC).2. To investigate the effects of ERC(N5) on the apoptosis and invasion behaviors of HUVEC.Methods1. Design and synthesis of ERC(N5) peptideThe RGD motif with its flanking sequences and C-terminal amino acids of Echistatin (Ech) were conjugated together with the mutation of [...]
Background: Glial tumors are the most common type of primary brain neoplasm andconstitute more than70%of all primary brain tumors. The most malignant histologicaltype is the glioblastoma, less than3%of glioblastoma patients are still alive at5years afterdiagnosis. Current treatment modalities for glioma patients including surgical resection,radiation therapy and chemotherapy, but most of glioblastoma patients survival time is [...]
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