Objective The purposes of research is to detect if rh-Eendostain has an inhibitive effect in the proliferation on human glioma cells.It aims to provide a theoretical basis for the drug screening.Methods (1)Human brain gliomas were cultured under the conditions:at 37℃, P <95% of the air in the DMDM medium. Digesting cells with 0.125% trypsin and [...]
Objective:1.To investigate the colchicine chemotherapeutic role on the proliferation of rat C6 glioma cells in vitro.2.To establish a reliable model of the rat brain glioma.3.To investigate the colchicine interstitial chemotherapy role on the general situation and survival time of the tumor-bearing rats in vivo.Methods:1.The rat C6 cells were divided into many colchicine treatment groups (2,1,0.5,0.25 [...]
ObjectiveTo prepare sustained-release poly(lactic-co-glycolic acid)(PLGA) microspheres containing docetaxel, and investigate the physiochemical properties, in vitro release and drug stability; and to investigate the effect and mechanism in treatment of human hepatoma-bearing nude mice by ultrasound-guided intratumor injection of the drug-loaded microspheres.Methods1. Sustained-release PLGA microspheres containing docetaxel were prepared by solvent evaporation method, thereafter morphology and [...]
Doxorubicin (DOX) is an antitumor anthracycline that represents the first-line therapeutic option in many hematological and solid tumors, but acute and chronic administration can produce serious cardiotoxicity. In order to reduce toxicity and increase the selectivity, the effective measures have been put into the development the drug delivery system.In this paper, we utilized natural protein-Zein [...]
OBJECTIVE The polymeric drug system delivered locally provides a novel modality of increasing therapeutic concentrations of drug for a prolonged period while decreasing systemic levels. In the current study, the cytotoxic activity of paclitaxel on human laryngeal cancer cell line Hep-2 was investigated in vitro. On the basis of the evidence that the Hep-2 cell [...]
The Investigation of Slow-release PLGA-Gemcitabine Microsphere in Treatmentment of Pancreatic Cancer
Object To study the acute toxicity and pharmacokinetics of slow-release PLGAGemcitabine microsphere and its antitumor effect on xenograft pancreatic tumor ir mice.Method Acute toxicity study: slow-release Gemcitabine was injected subcutaneously to healthy nude mice or to the tumor tissue of tumor bearing nude mice respectively. Up and down procedure was used to determine the LD50. [...]
Objective To evaluate the effectivity and safety of Temozolomide/PLGA microspheres in interstitutial chemotherapy. Furthermore, to explore the mechanism of Temozolomide/PLGA microspheres in C6 rat glioma. Additionally, to investigate the changes in C6 rat glioma after the combined chemotherapy with temozolomide/PLGA microspheres and Vatalanib.Methods Fifty SD male rats were injected with 2×10~6 C6 cells into the [...]
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