Objective To investigate the effects of recombinant human granulocyte colony-stimulating factor(rhG-CSF) on the expression of nuclear factor-kappaB(NF-ΚB) and induciable nitricoxide synthase(iNOS) in rats with focal cerebral ischemia/reperfusion. To explore the anti-inflammatory mechanisms of rhG-CSF, and to provide a new theoretical basis for clinical application.Methods Thirty-six male Sprague-Dawley rats were randomly divided into the sham-operated group, [...]
Backgrounds and Objectives: Sepsis is a systemic inflammatory response to thepresence of infection, mediated via the production of many cytokines, including tumournecrosis factor α (TNF-α), interleukin (IL)-6, and IL-1, as well as nitric oxide (NO) whichcauses changes in the circulation, increases endothelial permeability and actives thecoagulation pathways. These mechanisms play roles during septic shock, but [...]
Object This study was designed to investigate the mechanism of Berberine ameliorate the pathological physiology of heart failure in a model of chronic heart failure through the observe of serum tumor necrosis factor-a(TNF-a), interleukin-1(IL-1), interleukin-6(IL-6), interleukin-10(IL-10) and myocyte inducible nitric oxide synthase(iNOS) gene expression.Method The Sprague-Dawley(SD) rat of experimental heart failure (HF) model were established [...]
Objective:To investigate the machenism of donor liver NK cells alleviating actuerejection after liver transplantation by observing the secretion level of TGF-β1andIFN-γ in peripheral blood and the protein expression of Arg-1and iNOS in livertissues in acute liver graft rejection rat modelsMethods:Lewis rats were used as liver graft donors and BN rats asrecipients,”Lewis-BN” as acute rejection model [...]
Objective: The incidence of oral and maxillofacial cancer was 5-10 % accounts for systemic malignant tumor. Because oral and maxillofacial’s special anatomical location, the 5-year survival rate of oral cancer is only about 50%. It is a serious threat to people’s life and health. In this one, about about 90% of the oral cancer are [...]
Objective :Type 2 DM, which accounts for more than 90% of the DM cases globally, is characterized by hyperglycemia, peripheral resistance to the action of insulin, and eventual destruction of insulin producingβ-cells in the pancreas. Diabetic patients are at increased risk for cardiovascular disease, kidney and nerve damage, blindness and limb amputations. Resveratrol, a natural [...]
ObjectivesTo investigate the effect and possible mechanism of the derivative of cordycepin attenuates – Triacetyl-3-hydroxyphenyladenosine on early atherosclerosis of apoE-/- mice ,in order to provide scientific basis for the prevention and treatment of the early atherosclerosis.MethodsChoose fifty-one male ApoE-/- mice from The Chinese academy of medical sciences institute of experimental animals for this experiment. At [...]
Hello,My name is Jack,Ph.D. Supervisor, Welcome to My WebSite