Background Maintenance hemodialysis is the main renal replacement therapy for patients with end-stage kidney disease,In recent years,with hemodialysis equipment improvement and technological progress, hemodialysis patients significantly prolong their life. Then the complications and mental health problems are more outstanding, especially depression status. Depressed mood is the main characteristic of deprssion, its clinical manifestations can be [...]
Objective:To investigate the effect of lipopolysaccharide-activated complement on endothelial cell, and to evaluate the protective effect of the specific anticomplementary components on complement-injured endothelial cells and LPS-induced acute lung injury.Methods:The manner of LPS activating complement was characterized. Then the effects of LPS-activated complement on endothelial cells were determined. P-selectin, E-selectin and ICAM-1 were determined by [...]
Background:Inflammation and tumors are closely related. Inflammation is one of the most important factors in tumors development. HCC is the typical inflammation-related cancer. Chronic liver injury caused by chronic viral hepatitis, alcoholic liver and cirrhosis promotes the hepatocarcinogenesis and development, but the mechanism has not yet entirely clear. In this study, we research the effect [...]
Background Sleep deprivation (SD) means a complete lack of sleep time or less than optimal sleep time. Research results showed that sleep deprivation or lack of sleep time can lead to immune function reduced. Especially in the war time, wartime stress such as continuous fighting, night fighting, fighting across time zones can cause the body’s [...]
Background Sleep deprivation (SD) means a complete lack of sleep time or less than optimal sleep time. Research results showed that sleep deprivation or lack of sleep time can lead to immune function reduced. Especially in the war time, wartime stress such as continuous fighting, night fighting, fighting across time zones can cause the body’s [...]
Background and objective:Prostaglandin H synthase (PGHS), also known as Cyclooxygenase (COX), is the key enzyme in the biosynthesis of prostanoid and it plays an important role in the development of vascular inflammation such as atherosclerosis and post-angioplasty restenosis. Although selective inhibition of COX-2 increases the risk of heart attack and stock, little is known about [...]
Background Epidemiological and genetic data revealed that chronic inflammation could promote tumorigenesis. Tumor-associated macrophages (TAM) was major regulators between inflammation and cancer. TAM which was created in the tumor microenvironment displayed the function to promote tumorigenesis. Nuclear factor kB (NF-kB) was a key connection between inflammation and cancer. Lung cancer induced by coal tar was [...]
The effects of BCG on airway allergic diesase have received increasingly concerns. Clinical investigations demonstrate that there was a strong inverse association between delayed hypersensitivity to Mycobacterium tuberculosis and atopy, afterwards lots of studies support this view, many animal experiments demonstrate the protective effects of BCG on asthmatic mouse models. BCG-PSN consisted with nucleic acid [...]
Objective:Compare the size and function of omental cell from normal weight group and obesity group and to explore the pathogenesis of obesity, IR,T2DM et al obesity-related ailments.Methods:All participants were divided into two groups:normal control group BMI≤23 (kg/m2) and obese group BMI> 28(kg/m2), each group of 10 persons.Take its omental fat when they were surgerying at [...]
Objective:To investigate the effect of arecoline and extracellular calcium levels on the growth and expression of S100A7 mRNA in human keratinocytes(HaCaT cells),and to further gain insight into the pathogenesis of OSF.Methods:The effect of a 24-hour exposure of HaCaT to arecoline of various concertrations on the growth was measured by MTT,and RT-PCR was used for detecting [...]
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