Objective To investigate the effects of recombinant human granulocyte colony-stimulating factor(rhG-CSF) on the expression of nuclear factor-kappaB(NF-ΚB) and induciable nitricoxide synthase(iNOS) in rats with focal cerebral ischemia/reperfusion. To explore the anti-inflammatory mechanisms of rhG-CSF, and to provide a new theoretical basis for clinical application.Methods Thirty-six male Sprague-Dawley rats were randomly divided into the sham-operated group, [...]
Ginkgo biloba extract is one of the most important part of active ingredient intraditional Chinese dedicine, in clinical, it showed anti-fatigue, anti-oxidation, protectliver, improving blood circulation and a variety of other pharmacological effects. LPSis the main component of the cell wall of Gram-negative bacteria, LPS-mediatedactivation of macrophages leads to the production of various cytokines such [...]
Daphne giraldii Nitsche, belonging to Daphne L of Thymelaeaceae, and widelydistributes in Shanxi, Shaanxi, Sichuan, Qinghai and Gansu provinces. The barks ofrhizomes and stems of D. giraldii, commonly called ‘Zu Shi Ma’ in Chinese folk medicines,has been used to treat aches and rheumatism. Pharmacological investigations showed thatZushima had anti-inflammation, analgesia, anti-fertility, anti-tumor, anti-thrombotic,anti-malarial, sedative and [...]
Cisplatin is a chemotherapeutic agent used in the treatment of solid tumors likeovarian, testicular, cervical, lung, head and neck and bladder cancers. Dose limitingside effects of cisplatin include nephrotoxicity, neurotoxicity and ototoxicity. Whilenephrotoxicity can to some extent be reversed by increasing saline hydration as wellas mannitol diuresis, there are no known cures or preventative treatments [...]
AD (Alzheimer’disease) is one of the most common neurodegenerative diseases and the most common type in dementia, as characterized by senile plaques (SP) in the brain cortex, neurofibrillary tangles (NFT), a mass of neuron nuapoptosis and chronic and long term of inflammatory reaction which affected approximately35,600,000patients in the world in2010. The worse thing is the [...]
Objective: To evaluate the effects of Xuebijing Injection on white blood cell count (WBC), plasma levels of tumor necrosis factor alpha (TNF alpha), platelet count (Plt) in patients with sepsis.Therefor,this study can give a clue to the relatively reliable TCM reginmen in the evidence-based medicine.Methods:RCTs were identified (2008Jan-2011Sep) by multiple data-base electronic search (CNKI、VIP、WangFang).The studies [...]
ObjectiveChronic obstructive pulmonary diseases (COPD) is one of the most commoninflammatory disease of respiratory system. COPD has already become thepre-eminent heath problem worldwide, which mainly cause damage in lung and otherorgans at the same time. However, the detailed mechanisms of this disease are stillunclear. Recent studies have indicated that chronic inflammation is one ofrepresentative characters [...]
Chitosan which is derived from the partial deacetylation of chitin, is the onlycatnic polysaccharide in nature, it exhibits many particular phys chem properties andbioactivities. In previous, Chitosan has been found it had the effect of enhancingimmune responses, for example, activiting resident macrophage. But in currentresearch, we found that Chitosan also played an important role in [...]
Uterine leiomyomas are the most common pelvic benign tumors in women, occurring in women about35-50year of age. The incidence of leiomyomas is as high as51.2%-60%. Normal myometrium somatic mutations, the interaction between sex hormones and growth factors, oxidative stress, dysregulation of cell cycle and inflammation have been reported to be associated with the growth of [...]
Objective Though creating the intima injury model of rabbit carotid artery, observing the efficacy of ATRA on the tunica intima proliferation, the expression of MCP-1(monocyte chemotatic protein-1), TLR-4(Toll-like receptor4)in the injury and repair lesion located at the intima of the rabbit carotid artery, in order to study the possible mechanism of anti-inflammation of ATRA and [...]
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