Adult hippocampal neurogenesis is involved in the physiology and pathogenesis of various diseases and to develop dugs that enhance adult neurogenesis will be beneficial for the treatment of neuropsychological diseases. Major depression is a common mental disorder its incidence increased year by year. Depression will be the second leading illness in the world by2020as projected [...]
[Objective]To determine the effects on BRL-3A cellular proliferation and DNA damage induced by MC-LR with XRCC1 knocked down, then further to explore the role of XRCC1 in BRL-3A cells. Through the epidemiology survey in Fuzhou city of Fujian Province, to explore the relationship among the types of drinking water, miRNAs polymorphism of inflammatory pathway and [...]
[Objective]To determine the effects on BRL-3A cellular proliferation and DNA damage induced by MC-LR with XRCC1 knocked down, then further to explore the role of XRCC1 in BRL-3A cells. Through the epidemiology survey in Fuzhou city of Fujian Province, to explore the relationship among the types of drinking water, miRNAs polymorphism of inflammatory pathway and [...]
Background & Aims:There is increasing evidence for involvement of the low grade inflammation in the pathogenesis of irritable bowel syndrome (IBS) particularly post-infectious IBS (PI-IBS). The Nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome, an intracellular complex that regulates the release of proinflammatory cytokines interleukin-1β(IL-1β), have been revealed to play an important role in the [...]
Objective: To study relevant molecular expression of NLRP3 inflammasome signalling pathway and its association with clinical manifestations in peripheral blood mononuclear cells (PBMC) from patients with acute gouty arthritis (AGA) and healthy individuals; to explore the role of NLRP3 inflammasome signalling pathway in the pathogenesis of AGA.Methods: (1) 24 acute gouty arthritis patients and 24 [...]
Fas (CD95/Apo-1), a representative of tumor necrosis factor (TNF) receptor superfamily, triggers cell apoptosis following engagement by Fas ligand (FasL, CD95 ligand, TNFSF6) or by agonistic anti-Fas antibodies. It is generally accepted that Fas-mediated apoptosis is essential for the maintenance of immune homeostasis and immune privilege in brain, eye and testis. Fas-mediated apoptosis is considered [...]
Objectives:鈶燭o confirm AIM2 is a DNA sensor to detect HCMV;鈶o identify the influence of HCMV infection to the signaling molecules of AIM2 inflamasome pathway in THP-1-derived macrophages;鈶o confirm AIM2 inflammasome pathway involves in the pro-inflammatory cytokine response of innate immunity against HCMV infection.Methods:鈶燛stablished a cell model of HCMV infected THP-1-derived macrophages:HCMV (AD 169 strain) inoculated [...]
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