Objective To study the clinical efficacy of Dendritic Cells (DC) combined Cytokine-induced Killer cells (CIK) adoptive cellular immunotherapy for malignant tumors.Methods Peripheral blood mononuclear cells(PBMC) were isolated from21patients with malignant tumors using Blood Cell Separator. DC were induced from the adherent cells and the CIK cells were induced form the suspension cells. DC and CIK [...]
ObjectiveTo compare the efficacy and safety of sunitinib with immunotherapy in the treatment of renal cell carcinoma(RCC), summarize the experience of sunitinib in clinical practice and explore its clinical application.MethodsPatients treated with sunitinib in the first affiliated hospital of Zhengzhou University from June2008to December2011were enrolled in the study.The control group was those treated with IL-2and [...]
OBJECTIVE To investigate the expression of cancer testis antigen (CTA) MAGE-A3protein in human nasopharyngeal carcinoma patients as well as chronic inflammation of nasopharyngeal mucosa organization (rhinitis) patients and explore its feasibility in immunodiagnosis marker and immunotherapy of NPC.METHODS Investigating the expression of MAGE-A3antigen in tissues of51NPC patients as well as20chronic inflammation of nasopharyngeal mucosa organization [...]
Objective:To construct the transgenic recombinant vector of TRBO-Der f1and its expression in tobacco and to explore the effect of allergen specific immunotherapy of the major allergen group1(Der f1) from Dermatophagoides farinae (D. farinae) expressed in tobacco to allergic asthma.Methods1. Construction of transgenic recombinant vector of allergen group1from D. farinae and its expression in tobaccoThe total [...]
Alzheimer’s disease (AD) is a kind of age related neurodegenerative disease with the main clinical manifestations of cognitive impairment. Recently, Aβ oligomers are recognized as the main causative agent of AD in early neuron injury and pathogenesis. Based on our previous work, here we are going to investigate the effects of treatment of Aβ oligomer-selective [...]
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by confusion and impaired memory. Dynamin family is a GTPase and the essential role of dynamin in vesicle scission and synaptic function has been widely supported. In this study, we used different transgenic murine model of AD to detect the expression of dynamin to investigate the [...]
Objective: To detect the frequency of Treg in peripheral blood and tumor tissue of patients with renal cell carcinoma. To evaluate the relationship between frequency of Treg and prognosis of patients with renal cell carcinoma and the clinical effect of postoperative immunotherapy by testing the frequency of Treg in peripheral blood and tumor tissue of [...]
Objective: To detect the frequency of Treg in peripheral blood and tumor tissue of patients with renal cell carcinoma. To evaluate the relationship between frequency of Treg and prognosis of patients with renal cell carcinoma and the clinical effect of postoperative immunotherapy by testing the frequency of Treg in peripheral blood and tumor tissue of [...]
Objective: To detect the frequency of Treg in peripheral blood and tumor tissue of patients with renal cell carcinoma. To evaluate the relationship between frequency of Treg and prognosis of patients with renal cell carcinoma and the clinical effect of postoperative immunotherapy by testing the frequency of Treg in peripheral blood and tumor tissue of [...]
Objective: To detect the frequency of Treg in peripheral blood and tumor tissue of patients with renal cell carcinoma. To evaluate the relationship between frequency of Treg and prognosis of patients with renal cell carcinoma and the clinical effect of postoperative immunotherapy by testing the frequency of Treg in peripheral blood and tumor tissue of [...]
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