Objective: To investigate the effect of exogenous hydrogen sulfide （H2S） on ferricchloride （FeCl3）-induced thrombosis in SD rat carotid and examine the possiblemechanisms involved.Methods: Male SD rats, weight320-400g, were used in this stduy. In brief, the ratcarotid artery was dissected from other tissues.10%FeCl3solution was then appliedonto the carotid artery for5min to induce arterial thrombosis. the blood [...]
Objective To explore the efects and mechanisms of Hydrogen Sulfide on lipidendocytosis in vascular smooth muscle cells and provide a new compelling evidence forprevention of the atherosclerosis.Methods Vascular smooth muscle cells（VSMCs） were isolated from abdominal aortaof healthy SD rats which were cultured in10%FBS Deulbecco’s Modified EagleMedium（DMEM） at37℃in a humidified atmosphere containing5%CO2. Cells crawl outat3to5days, and [...]
Background and Objective:Post-operative cognitive dysfunction (POCD) is a common complication of central nervous system following anesthesia and surgery in elderly populations. It mainly refers to deficits of cognitive functions including learning and memory, and may persist for weeks, months, or even may be a permanent presence. However, the precise pathogenic mechanisms remain unknown. Studies have [...]
Objective:Hydrogen sulfide is endogenously produced in the mammalia- n vasculature from the amino acids cysteine and homocysteine by the pyridoxal-5,-phosphate-dependent enzyme cystathionine-γ-lyase（CSE）. For a long time, Hydrogen sulfide has been thought as a kind of gas colorless, poisonous and smelling of rotten egg. It can cause the serious damage to many tissue and organs, even [...]
Objective Through observing the alteration of Nitric Oxide in serum of burned rat intervened by sodium hydrogen sulfide to explore the impact of hydrogen sulfide to Nitric Oxide of burned rat.Methods 64 SD rats were randomly divided into burned group and intervention group （32 rats in each group）; each group was then divided as pre-burn [...]
Objective By observing the change of cystathionine-γ-lyase (CSE) in the level of mRNA in lung and content of H2S in blood in rats with acute pancreatitis associated lung injury, combined with the change of TNF-αin the level of mRNA and pathological changes in lung tissue to explore the relationship between hydrogen sulfide / cystathionine -γ- [...]
Objective By observing the change of cystathionine-γ-lyase (CSE) in the level of mRNA in lung and content of H2S in blood in rats with acute pancreatitis associated lung injury, combined with the change of TNF-αin the level of mRNA and pathological changes in lung tissue to explore the relationship between hydrogen sulfide / cystathionine -γ- [...]
Objective To investigate the effect of hydrogen sulfide （ H2S ） on pancreatic injury in rats with acute necrotizing pancreatitis,and to explore the possible mechanism in this model.Method A totole of 28 SD rats were radomly divided into the control group,ANP group,the Intervention group which includes prophylactic group （”prop group”） that was administered with PAG [...]
Objective: Coronary heart disease is the common cardiovascular disease, also known as ischemic heart disease (IHF). Myocardial ischemia, necrosis for a long time cause ischemic heart failure eventually. The elderly is a high incidence group of ischemic heart disease. With the increasing incidence of coronary heart disease, the incidence of elderly patients with IHF is [...]
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