BackgroudA major risk factors of atherosclerotic cardioascular disease is aging. The morbidity of hypertension, coronary disease and shock rise signif ieantly. Although AS is known as chronic inflammatory disease, more and more evidence suggested that cell seneseence is one of the main causes of organism aging and diseases including atherosclerosis and hypertension. Therefore, studies on [...]
Objective: To explore the effects of uric acid (UA) on C-reactive protein(CRP) expression and study on the mechanism of oxidative stress in humanumbilical vein endothelial cells (HUVECs).Methods: Different concentrations of UA (0mg/dl, 4mg/dl, 8mg/dl,12mg/dl, 16mg/dl) were incubated 12h with HUVECs, and HUVECs werestimulated with 12mg/dl UA at different time (6h, 12h, 24h, 48h). CRPmRNA and [...]
BackgroudA lot of research surveys have shown that cigarette smoking could damage the vascular endothelial cells and lead to vascular endothelial cells dysfunction, increasing the risk of thrombosis. In recent years, the relationgship beween endothelial cell protein C receptor and thrombosis aroused great attention from academic circle. When a variety of factors lead to endothelial [...]
Objective:To observe the effects of shanmai capsules on the blood pressure in renovascular hypertensive rats by “two-kidney one-clip”method and on vascular endothelial function, study the antihypertensive effect of shanmai capsules, and discuss the mechanism of shanmai capsules promote antihypertension from regression of atherosclerosis.Methods:(1) Established renovascular hypertensive model in rats by “two-kidney one-clip”method.(2) To observe the [...]
Objective: To establish a insulin resistance (IR) model induced by high glucosein vascular endothelial cells; to observe the improvement effect of PPARγ activationon IR induced by high glucose in vascular endothelial cells and explore itsmechanism.Methods: Human umbilical vein endothelial cells (HUVECs) were inoculated incells petri dishes and randomly divided into four groups:(1) the control group(Control): [...]
Objective: To establish a insulin resistance (IR) model induced by high glucosein vascular endothelial cells; to observe the improvement effect of PPARγ activationon IR induced by high glucose in vascular endothelial cells and explore itsmechanism.Methods: Human umbilical vein endothelial cells (HUVECs) were inoculated incells petri dishes and randomly divided into four groups:(1) the control group(Control): [...]
Objective: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. Along with the wide application of immunosuppressant, disability rate has dropped significantly. But as the chronic complications, cardiovascular disease have become one of the main death causes of RA patients. Moreover early onset of atherosclerosis possess higher proportion. Now, most of scholars think that atherosclerosis [...]
Objective: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. Along with the wide application of immunosuppressant, disability rate has dropped significantly. But as the chronic complications, cardiovascular disease have become one of the main death causes of RA patients. Moreover early onset of atherosclerosis possess higher proportion. Now, most of scholars think that atherosclerosis [...]
ObjectiveTo observe the effects of Fasudil Hydrochloride on the injury of HUVECs induced by AngiotensinⅡ（ AngⅡ）, which influence on the change of cytoskeleton and the expression of Rho associated kinase（ROCK） and Phospho-myosin light chain（P-MLC）, and explore the possible molecular mechanisms of Fasudil Hydrochloride in cytoskeleton of the injuried HUVECs.MethodsNeonatal umbilical cord were digested into the [...]
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