Objective:To observe the stabilization of atherosclerotic atheroma of 7-difluoromethyl-5,4′-dimethoxygenistein(DFMG), a novel genistein(GEN) analogue, on atherosclerosis in a rabbit model in vivo, and investigate whether the mechanism underlying DMFG stabilize Atherosclerotic Atheroma is involved in the inhibition of inflammatory factors secretion and adhesion molecules release in vascular endothelial cells.Methods:Immunohistochemistry for mouse monoclonal antibodies against rabbit a-smooth [...]
Objective:To observe the stabilization of atherosclerotic atheroma of 7-difluoromethyl-5,4′-dimethoxygenistein(DFMG), a novel genistein(GEN) analogue, on atherosclerosis in a rabbit model in vivo, and investigate whether the mechanism underlying DMFG stabilize Atherosclerotic Atheroma is involved in the inhibition of inflammatory factors secretion and adhesion molecules release in vascular endothelial cells.Methods:Immunohistochemistry for mouse monoclonal antibodies against rabbit a-smooth [...]
Diabetes mellitus is a chronic metabolic disease in recent year,which harms human health and life seriously. According to statistics, vascular disease is the main cause of death for patient with diabetes mellitus. How to decrease the occurrence of vascular disease is a matter of great urgency. Controlling blood glucose is the first measure in diabetes [...]
Objective:To observe the stabilization of atherosclerotic atheroma of 7-difluoromethyl-5,4′-dimethoxygenistein(DFMG), a novel genistein(GEN) analogue, on atherosclerosis in a rabbit model in vivo, and investigate whether the mechanism underlying DMFG stabilize Atherosclerotic Atheroma is involved in the inhibition of inflammatory factors secretion and adhesion molecules release in vascular endothelial cells.Methods:Immunohistochemistry for mouse monoclonal antibodies against rabbit a-smooth [...]
Cigarette smoking is an important risk factor for cardiovascular diseases, including myocardial infarction, coronary heart disease, cerebrovascular diseases, aortic aneurysm, peripheral vascular diseases, et al. It was reported that about 1.6 millions of cardiovascular deaths were caused by cigarette smoking worldwide in 2000. Smoking was shown to increase inflammation and oxidative stress, leading to endothelial [...]
Endothelial dysfunction is atherosclerosis (atheriosclerosis, As) part of the initiating vascular complications.Adenosine monophosphate (AMP) activated protein kinase (AMP-activated protein kinase, AMPK) as an important protein kinases involved in many metabolic processes, known as a “cellular energy regulator” that the perception of the state of cellular energy metabolismchange, and by affecting multiple aspects of cell metabolism [...]
In this work,titanium oxide(Ti-O)films were synthesized using Unbalance Magnetron Sputtering(UBMS).To obtain hydroxyl group,the films were treated by plasma immersion H~+ ion implantation.The films were then activated by acid solution.After that,aminopropyltriethoxysilane(APTE)was covalently interacted with the hydroxyl on the Ti-O film surface from activation.Then, laminin(Ln)and fibronectin(Fn)were covalently immobilized to the surface by the amidogen of APTE.Scanning electron [...]
BACGROUNDCD40/CD40L system is proven to be an important mediator in the regulation of Lymphocytes activation and the course of humoral immunity. Recent study has demonstrated that CD40/CD40L expressed on the endotheliocyte and played a critical role in the activation of proatherogenic pathways,the progression of atherosclerosis and the development of vulnerable plague.Our previous work show calcium [...]
ObjectivesTo research the fluoride effects on cultures human umbilical vein vascular endothelial cells;To research the selenium effects on cultures human umbilical vein vascular endothelial cells;To research the selenium effects on HUVEC injured by fluride.Metheds HUVEC were cultured under the condition of 37℃,5%CO2,saturation humidity.When HUVEC lied in logarithm growth,we divided them into 3 experiment groups which [...]
Objective:To study the effect of Polysaccharide L01 from Laminaria on the expression and secretion of inducible nitric oxide synthase（iNOS）,endothelial nitric oxide synthase（eNOS）,prostaglandin I2（prostacyclin）（PGI2）stimulated by Lipopolysaccharide in cultured human umbilical vein endothelial cell （HUVEC）,thus providing an experimental basis for developing a new drug for antithrombosisMethods:（1）The human umbilical vein endothelial cell was divided into 7 group randomly [...]
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