Cigarette smoking is an important risk factor for cardiovascular diseases, including myocardial infarction, coronary heart disease, cerebrovascular diseases, aortic aneurysm, peripheral vascular diseases, et al. It was reported that about 1.6 millions of cardiovascular deaths were caused by cigarette smoking worldwide in 2000. Smoking was shown to increase inflammation and oxidative stress, leading to endothelial […]

With the aging of global population, cardiovascular and cerebrovascular disease has became one of major threats to the human Health,with high morbidity and mortality. Atherosclerosis (AS) is a complicated multiple-factorial disease, which is the initiation or aggravation of these severe cardiovascular and cerebrovascular diseases. Its precise pathogenesis is still unknown. The research on the pathogenesis […]

Endothelial dysfunction is atherosclerosis (atheriosclerosis, As) part of the initiating vascular complications.Adenosine monophosphate (AMP) activated protein kinase (AMP-activated protein kinase, AMPK) as an important protein kinases involved in many metabolic processes, known as a “cellular energy regulator” that the perception of the state of cellular energy metabolismchange, and by affecting multiple aspects of cell metabolism […]

Objective:To observe the stabilization of atherosclerotic atheroma of 7-difluoromethyl-5,4′-dimethoxygenistein(DFMG), a novel genistein(GEN) analogue, on atherosclerosis in a rabbit model in vivo, and investigate whether the mechanism underlying DMFG stabilize Atherosclerotic Atheroma is involved in the inhibition of inflammatory factors secretion and adhesion molecules release in vascular endothelial cells.Methods:Immunohistochemistry for mouse monoclonal antibodies against rabbit a-smooth […]

Objective:To observe the stabilization of atherosclerotic atheroma of 7-difluoromethyl-5,4′-dimethoxygenistein(DFMG), a novel genistein(GEN) analogue, on atherosclerosis in a rabbit model in vivo, and investigate whether the mechanism underlying DMFG stabilize Atherosclerotic Atheroma is involved in the inhibition of inflammatory factors secretion and adhesion molecules release in vascular endothelial cells.Methods:Immunohistochemistry for mouse monoclonal antibodies against rabbit a-smooth […]

Diabetes mellitus is a chronic metabolic disease in recent year,which harms human Health and life seriously. According to statistics, vascular disease is the main cause of death for patient with diabetes mellitus. How to decrease the occurrence of vascular disease is a matter of great urgency. Controlling blood glucose is the first measure in diabetes […]

Objective:To observe the stabilization of atherosclerotic atheroma of 7-difluoromethyl-5,4′-dimethoxygenistein(DFMG), a novel genistein(GEN) analogue, on atherosclerosis in a rabbit model in vivo, and investigate whether the mechanism underlying DMFG stabilize Atherosclerotic Atheroma is involved in the inhibition of inflammatory factors secretion and adhesion molecules release in vascular endothelial cells.Methods:Immunohistochemistry for mouse monoclonal antibodies against rabbit a-smooth […]

Cigarette smoking is an important risk factor for cardiovascular diseases, including myocardial infarction, coronary heart disease, cerebrovascular diseases, aortic aneurysm, peripheral vascular diseases, et al. It was reported that about 1.6 millions of cardiovascular deaths were caused by cigarette smoking worldwide in 2000. Smoking was shown to increase inflammation and oxidative stress, leading to endothelial […]

Endothelial dysfunction is atherosclerosis (atheriosclerosis, As) part of the initiating vascular complications.Adenosine monophosphate (AMP) activated protein kinase (AMP-activated protein kinase, AMPK) as an important protein kinases involved in many metabolic processes, known as a “cellular energy regulator” that the perception of the state of cellular energy metabolismchange, and by affecting multiple aspects of cell metabolism […]

In this work,titanium oxide(Ti-O)films were synthesized using Unbalance Magnetron Sputtering(UBMS).To obtain hydroxyl group,the films were treated by plasma immersion H~+ ion implantation.The films were then activated by acid solution.After that,aminopropyltriethoxysilane(APTE)was covalently interacted with the hydroxyl on the Ti-O film surface from activation.Then, laminin(Ln)and fibronectin(Fn)were covalently immobilized to the surface by the amidogen of APTE.Scanning electron […]