Background and objective:Primary hepatic carcinoma is mainly hepatocellular carcinoma (HCC). It is a common clinical tumor with high malignancy and fatality rate. Its main biological characteristic is hadro-invasion, easy recurrence, metastasis and poor progosis. At present, there are many treatments of HCC, such as surgery, radiotherapy, chemotherapy and other kinds of treatments. Because of their [...]
Objective:Background:In recent years, transarterial chemoembolization (TACE) is widelyemployed due to its good efficacy and is used to treat hepatocellular carcinoma, especially in advanced liver cancer. It is well-known that the liver has dual blood supply from both the portal vein and the hepatic artery. However, the vascularization of hepatocellular carcinoma (HCC) is mostly dependent on [...]
Objective:To discuss the clinical value of dual-source CT perfusion imaging(CTPI) in estimating the therapeutic efficacy of transcatheter arterial chemoembolization (TACE) by gelatin sponge particles for hepatocellular carcinoma(HCC).Methods:Dual-source CTPI was performed in 20 patients with HCC 1-3 days before and 6-8 days after TACE by gelatin sponge particles.The original imaging data was reconstructed in workstation to [...]
Objective To detect the expression of epidermal growth factor (EGF), transforming growth factor-1(TGF-β1)and c-myc in patients with hepatocellular carcinoma and normal liver tissue. To investigated the differences of clinicopathological factors(gender, age, tumor diameter, metastasis, differentiaion) in hepatocellular carcinoma.to analyzed the relationships between three factors in hepatocellular carcinoma development, and provide evidence for hepatocellular carcinoma early [...]
Objective To investigate the expression and clinical value of human telomerase reverse transcriptase(hTHRT) mRNA and gamma-glutamyl transpeptidase (GGT) mRNA in the peripheral blood of small HCC patients.Methods RT-PCR was used to detect the expression of hTERT mRNA and GGT mRNA in the peripheral blood of 30 patients with small HCC,18 patients with benign liver diseases [...]
Objective To compare respiratory-triggered (RT) and breath-hold (BH) diffusion-weighted imaging (DWI) in assessing therapeutic effect of transarterial chemoembolization (TACE) for hepatocellular carcinoma.Methods Institutional review board approved this study, and all informed consent were obtained.24 clinically-diagnosed hepatocellular carcinomas (HCCs) (mean diameter,6.6cm; range,1.7-13.1cm) of 18 patients (17men,1 woman; mean age, 53.5 years; range,35-74 years) from August 2010 [...]
Background:Inflammation and tumors are closely related. Inflammation is one of the most important factors in tumors development. HCC is the typical inflammation-related cancer. Chronic liver injury caused by chronic viral hepatitis, alcoholic liver and cirrhosis promotes the hepatocarcinogenesis and development, but the mechanism has not yet entirely clear. In this study, we research the effect [...]
Aim:To evaluate in vivo anti-hepatoma effect of arenobufagin and explore probable molecular mechanisms of arenobufagin-induced apoptosis in doxorubicin-sensitive and -resistant human hepatoma cells (HepG2 and HepG2/ADM), and further study inhibitory effect of arenobufagin on the invasion and migration of HepG2 cells. Methods:S180 sarcoma and H22 hepatoma animal model in KM mice, together with orthotopic transplantation [...]
[Objective] Hepatocellular carcinoma(HCC) is one of the most common malignant tumors with limited treatment options. The hepatocarcinogenesis involves a series of mechanisms, such as gene mutation, cellular signal transduction, tumor neovascularization and so on. In the last decades, in addition to genetic alterations, epigenetic inactivation of tumor suppressor genes by promoter hypermethylation has been recognized [...]
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