Objective:Observe the effect to suppress the growth of H22liver tumor model and safety of recombinant human endostatin (Endostar) work together with Oxaliplatin or Cinobufacini, and investigate the mechanism.Methods:Establish mouse subcutaneous H22liver tumor model. It is about one week for the tumor reach to100mm3.Part1:ninty-six mice with subcutaneous H22liver tumor were divided into six groups randomly as [...]
ObjectiveTo study the effect of breast cancer associated fibroblast (CAFs) on breastcancer sells in vitro.MethodsThe CAFs and non-cancer associated fibrolasts (NAFs) were isolated fromprimary breast tumors and their paired normal breast tissue. The CAFs and NAFswere cultured in1640medium without the supplement of serum, and the supernatantwere collected.Breast cancer cell lines MCF-7and MDA-MB-468were cultured inthe collected [...]
Objective:Effects and mechanism of quercetin on proliferation, apoptosis, Invasion and metastasis of hepatocarcinoma cell line HCCLM6were studied so as to illustrate the anti-tumor mechanism of quercetin, and further theoretical evidence of which as an anti-tumor drug may be provided.Methods:1.HCCLM6cells dealt with different concentrations quercetin (20、40、60、80、100μmol/L) were then analyzed by MTT assay to calculate the cells’survival [...]
Objective:To investigate the inhibitory action of small molecular peptide from Centipede and its mechanism on nude mice model of human hepatocellular carcinoma by using orthotopic transplantation.Method:1. To use the Enzyme-Decomposition method obtained the crude extracting of Centipede which was injected into nude mouse after separated and purified by using the Sephadex G-25gel chromatography2. Chose five [...]
Objective:To explore the relationship of Ornithogalum Caudatum Ait saponins and the expression of VEGF,and CyclinDl in liver cancer. To explore a new way of Tradtional Chinese medicine prevent liver cancer.Methods:Ornithogalum Caudatum Ait saponin extract, diethylnitrosamine induced hepatocarcinogenesis. Ornithogalum Caudatum Ait saponins interfere with, the use of conventional HE staining and pathological changes in liver tissue. [...]
Background :As a key of signaling pathways in the development of animal,Wnt signaling pathways involved in embryonic development from nematodes to humans and maintain adult normal structure of metabolism . It is an open signal pathway that it have lots of sites to be effected. This transduction pathway is extensive activation to regulate cell growth, [...]
BACKGROUND & PURPOSE: Herpes simplex virus thymidine kinase (HSV-TK) gene/ganciclovir (GCV) has been wildly used as a traditional gene therapy modality, and the sodium/iodide symporter gene (NIS) has been found to be a novel therapeutic gene. However, the therapeutic effects of both genes need to be enhanced. The purpose of this study was to investigate [...]
Objective （1） To observe the role of hypocaloric nutrition support after liver resection in patients with liver cancer. （2） To observe the role of different Medium- and Long-Chain triglyceride after hepatectomy in patients with liver cancer. （3） To observe the role of Structured triglyceride after hepatectomy in patients with liver cancer.Methods （1） 49 cases after [...]
Objective To establish combining hepatocarcinoma disease and abnormal savda syndromes rats model, and investigate the effect of abnormal savda on inducing and developing process of hepatocirrhosis phase in this model. Methods Under the direction of uighur traditional medicine, multi complcated induction methods were used to establish abnormal savda syndromes rats model for three weeks, using [...]
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