As it is known to all that activated hepatic stellate cells (HSCs) play a central role in liver fibrogenesis, Sail et al thought it is hard to be inverted from activated HSCs to the quiescent ones. but apoptosis of activated the critical HSCs might be essential to clear HSCs from injured liver. At present, decreasing [...]
As it is known to all that activated hepatic stellate cells (HSCs) play a central role in liver fibrogenesis, Sail et al thought it is hard to be inverted from activated HSCs to the quiescent ones. but apoptosis of activated the critical HSCs might be essential to clear HSCs from injured liver. At present, decreasing [...]
Chronic liver disease is a kind of serious harm to human health worldwide,Hepatic fibrosis is middle and key element of this process.The main pathological characteristic of hepatic fibrosis is the increased deposition of newly formed extracellular matrix(ECM),resulting from a shifted balance between collagen synthesis and degradation.Though the pathogenesis of diverse hepatic diseases is different,the ultimate [...]
It is well known that the critical event of liver fibrosis is that hepatic stellate cells(HSCs)become active, the increasing of production and secretion of extracellular matrix(ECM)and the decreasing of degradation of them result in the accumulation of over ECM in the liver. In recovery period, the apoptosis of HSCs increase significantly, on the one hand [...]
[Background and Objective]Hepatic fibrosis which is characterized by the activation and proliferation of hepatic stellate cell (HSC), associated with the production and deposition of extracellular matrix (ECM) in the Disse’s space is a pathological response to various chronic liver diseases. As successful approaches to gene therapy on hepatic fibrosis, repressing activation and proliferation of HSC, [...]
Hepatic fibrosis is a kind of severe disease with high morbidity and mortality, and its common pathological feature is over-aggradation of extracellular matrix （ECM）. The activation of hepatic stellate cell （HSC） is critical step in the development of liver fibrosis. Proliferation and fibrogenesis of activated HSC are attributed to over-aggradation of ECM. There have been [...]
Objective To explore the effect of regulating extracellular signal regulated kinase (ERK) -1 on the biological behaviors of hepatic stellate cells (HSC).Methods The inhibition rate of siRNA on ERK-1 expression of HSC was determined by Western blot and RT-PCR. After the ERK-1 gene silencing, the proliferation of HSC was determined with MTT assay. HSC cycle [...]
Total flavones of Bipinnata L（TFB） were extracted from the leaves of Bidens pilosa L, which has been preliminarily assessed to be of protection against acute liver injury given via intragastric administration（ig） route.To further explore the effect of total flavones of Bidens Bipinnata L（TFB） on experimental liver fibrosis,the experimental model was induced by CCl4（50%,0.1 mL/100 g [...]
Background and ObjectiveHepatic fibrosis,characterized by the overproduction and accumulation of hepatic extracellular matrix（ECM）,was the common and important pathological changes in the chronic liver diseases,through which the chronic hepatitis developed into cirrhosis.It was acknowledged that hepatic cirrhosis couldn’t be reversed,while hepatic fibrosis could. Hepatic stellate cell（HSC） was the main resource of hepatic ECM and the cellular [...]
【Background and Objective】Hepatic fibrosis,characterized by deposition of extracellular matrix(ECM) in the Disse’s space,is a pathological response to a variety of chronic liver diseases,which is recognized as a dynamic and reversal process.Therefore,blocking,inhibition or even reversal of hepatic fibrosis is a major target for the treatment of chronic liver disease.Generally,it has been accepted that activated hepatic stellate [...]
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