Part I:Loureirin B on experimental hepatic fibrosis and its possible mechanismObjective:To investigate Loureirin B on experimental hepatic fibrosis, and present possible mechanisms。Method:36clean male SD (Sprague-Dawley) rats were randomly divided into4groups:Control group, model group, drug treatment group; With thioacetamide (TAA) inducing liver fibrosis model, to bserve serum transaminase (ALT, AST), fibrosis markers (HA, LN, IV-C), liver [...]
Hepatic fibrosis, results from excessive deposition of extracellular matrix （ECM） in the liver. More fibrous tissues will be produced if the chronic liver injury continues, and finally turn to be liver cirrhosis. Liver fibrosis is reversible, while the liver cirrhosis is not. Since hepatic fibrosis is the former process of liver cirrhosis, it is necessary [...]
Objective: Hepatic fibrosis, the liver’s wound healing response to a variety of acute or chronic liver injury, is an important pathologic character in many kinds of chronic liver disease. And it will induce hepatic cirrhosis. In some circumstance, hepatic fibrosis was reversible. The main pathological characteristic of hepatic fibrosis is increased irregular deposition of extracellular [...]
Objective: Hepatic fibrosis, the liver’s wound healing response to a variety of acute or chronic liver injury, is an important pathologic character in many kinds of chronic liver disease. And it will induce hepatic cirrhosis. In some circumstance, hepatic fibrosis was reversible. The main pathological characteristic of hepatic fibrosis is increased irregular deposition of extracellular [...]
Hepatic fibrosis is a significant health problem worldwide for which no effective therapy exists. Hepatic stellate cell (HSC) plays a critical role in the live fibrosis. HSC has dominated studies which are about mechanisms of liver fibrosis over the last two decades. Following hepatic injury, HSC becomes activated, proliferate and produce extracellular matrix (ECM), of [...]
Liver fibrosis is that diffuse liver extracellular matrix （especially collagen） excessively depose. It is not an independent disease, but it is the common pathological process of many chronic liver disease, including alcohol, viral infections, genetic metabolic, self-Immunity, and so can lead to liver fibrosis. Currently, most anti-hepatic fibrosis drugs had no significant clinical effect, or [...]
Liver fibrosis is the development of most chronic liver diseases,at the same time, is also common to the pathological process of cirrhosis, chronic liver injury is healing response for a reversible process. At present, the incidence of various liver diseases is rising, they are accompanied by hepatic fibrosis ( hepatic fibrosis, HF), eventually develop into [...]
Liver fibrosis is the development of most chronic liver diseases,at the same time, is also common to the pathological process of cirrhosis, chronic liver injury is healing response for a reversible process. At present, the incidence of various liver diseases is rising, they are accompanied by hepatic fibrosis ( hepatic fibrosis, HF), eventually develop into [...]
Liver fibrosis is the development of most chronic liver diseases,at the same time, is also common to the pathological process of cirrhosis, chronic liver injury is healing response for a reversible process. At present, the incidence of various liver diseases is rising, they are accompanied by hepatic fibrosis ( hepatic fibrosis, HF), eventually develop into [...]
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with an annual incidence rate of about 600,000 cases, and the incidence and death of HCC are still on an upward trend. HCC incidence and deaths of China account for more than half of those of the world. Most of HCCs in China are [...]
Hello,My name is Jack,Ph.D. Supervisor, Welcome to My WebSite