Objective:To explore the protective effects of transplantation of Di Huang Yin Zi incubate bone marrow stromal stem cells on rats ischemic brain injury by means of ischemic brain injury in rats for the research object; by observing the nerve cell apoptosis and the expression changes of HSP70 and VEGF gene after cerebral ischemic injury, to [...]
Objective:To explore the relationship between the endoplasmic reticulum stress in placenta tissues and the pathogenesis of preeclampsia.Methods: Thirty preeclampsia patients (PE group), hospitalized in Department of Obstetrics first affiliated hospital of Nanjing Medical University from July 2009 to January 2010,were selected as the subject group and 35 normal pregnant women as control group. Electron Microscopy [...]
colorectal cancer is a most common clinical type of tumor and liver is the most frequent transferred body part of this cancer. After this cancer shifting to the liver, its curative effect will be less optimistic ,and natural survival period will be short. If it is removed ,the prognosis will be improved. In recent years, [...]
Study Objective:Epidemiology data demonstrate that regular exercise can reduce the morbidity and mortality of cardiovascular diseases by 40-50%.One of the mechanisms known is exercise induced myocardial protection.However,the exact mechanisms of myocardial protection are not clear yet.In this study,the effects of long-term exercise with medium intensity on cardiac function,as well as the effects on heat shock [...]
Background and aims:Heat shock proteins are a set of proteins ubiquitously expressed among prokaryotic and eucaryotic organisms,which are highly conserved and cytoprotective,playing a regulative role in the growth, development,differentiation and apoptosis of cells.To maintain the normal morphology and function of cells,HSPs can be induced under variety of stresses, such as inflammation,ischemia,neoplasms,especially hyperthemia.Recent studies have indicated [...]
Multiple myeloma(MM) is an incurable plasma cell malignancy with a terminal phase marked by increased proliferation and resistance to therapy.Arsenic trioxide(ATO),an antitumor agent with a multifaceted mechanism of action,displayed clinical activity in patients with late-stage multiple myeloma.However,the precise mechanism(s) of action of ATO has not been completely elucidated.AIM:To use proteomics to analyze the ATO-induced protein [...]
Objective To investigate whether allogeneic dendritic cells pulsed with heat-shock tumor cell lysates(hTCL) could induce antitumor responses Against Lung Cancer mediated by T-cell.Methods hTCL or tomor cell lysates (TCL) extracted from NSCLC patients were used to pulse DCs from patients or Allogeneic donors, and with suitable condition, peripheral blood mononnclear cells(PBMCs) were elicited to response [...]
The effects of K+ channels blockers on the proliferation in human cervix carcinoma cell LinesOBJECTIVE: Variant types of K+ channels are known to be involved in the proliferation of a number of malignant cell lines. To explore the role of different subtypes of K+ channels, especially the maxi-conductance Ca2+-activated K+ channels, in the proliferation of [...]
Heat-shock protein 70 (HSP70), a member of HSPs family, is a highly conserved chaperone protein involved in protein assembling, folding, transportation and antigen processing and presenting. The increased expression of HSP70 can be found in various stressful conditions including Hantavirus (HV) infection in our previous research. HV are rodent-borne, enveloped RNA viruses in the family [...]
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