Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide andcauses more than500,000deaths annually[1]. In the United States, the incidence of HCChas increased by more than90%in the past three decades. Despite great achievementshave been obtained in HCC diagnosis and therapy, the morality rate remains high,especially for advanced HCC when the disease is usually diagnosed. Adriamycin [...]
LKB1, also known as STK11, is a serine/threonine kinase. LKB1has recently been shown to be frequently mutated in cancer, such as liver cancer, lung cancer and cervical cancer, thus defining LKB1as a tumor suppressor protein. The human LKB1tumor suppressor has been implicated as an important regulator of many cellular processes and signaling pathways, including the [...]
Primary liver cancer (PLC) is one of the common malignant tumors. The incidence of PLC has risen in recent years. It is in fifth place, every year the new patient is about622,000and the death rate in third place. In our country, the new patients are about340,000every year, nearly110,000die from PLC, which in second place.This disease [...]
Background:Hepatocellular carcinoma (HCC) is a common malignant tumor, it is also one of the death cause among the three global cancer. POLD1encodes the125-kDa catalytic subunit of DNA polymerase δ. In the S phase, the complex of P125and proliferation cell nuclear antigen (PCNA) and replication factor C (RFC), positioning in the replication fork, that the DNA [...]
HCC is a complex disease caused by multiple genes and influenced by multiple factors. The fatality rate of HCC in malignant tumor is ranked top in our country and even the worldwide. The molecular mechanism of hepatoma, including the factors related to hepatocarcinogenesis, the search of the biological marker and treatment target referred to the [...]
Liver cancer is a malignant tumor and its prognosis is poor. At present various treatmentscan not fundamentally change the prognosis of patients with liver cancer. Gene-viral treatmentbecame a kind of new treatments began to used in the treatment of liver cancer. Interleukin inimmune response and adjust the play an important role. IL-21is mainly secreted by [...]
Objective:In order to further research the suppression of has-miR-99a on proliferation ofhepatocellular carcinoma cells through constructing adenovirus vector.Methods:Expression of miR-99a was detected by quantitative real-time polymerase chainreaction (qRT-PCR) in HCC. The adenovirus vector Ad5-miR-99a were constructed.Through the Luciferase Reporter Assay found that miR-99a regulation of the new target genesEIF2C2. Then we detected EIF2C2and downstream PTEN [...]
Hepatocellular carcinoma is a kind of malignant tumor which happened in liver cell orintrahepatic bile ducts cells with high malignant degree, fast progress and poor prognosis.Its incidence ranks sixth in malignant tumors and the death rate in third. Unfortunately,about half of HCC patients concentrated in China, seriously endangers our people’s health.In recent years, through technologies [...]
OBJECTIVE:(1)、Observe the anti-tumor activity of melittin on HCC cell line;(2)、Observe the cell cycle arrest of melittin on HCC cells;(3)、To detect the regulation ofmelittin on HMGB1and related pathway.METHODS:(1) We first observe the anti-tumour activity of melittin on HCC cell line.Cell morphology and MTT assay were used to determine the growth inhibition effect ofmelittin.(2) Cell cycle arrest [...]
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers and the5thleading cause of cancer-related deaths worldwide. Although radical hepatectomy isconsidered as one of the first line treatment for patients with early HCC, the surgicaloutcome is far from satisfactory due to the likelihood of intrahepatic and extrahepaticrecurrence. Meanwhile, the number of the early stage HCC [...]
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