Objective:To study the right infusion doses of sufentanil in glioma surgery by using total intravenous anesthesia with target-controlled infusion (TCI) of propofol combined with sufentanil, and observing the change of hemodynamic and the level plasma cortisol.Methods:Sixty patients, ASA I-II, scheduled to undergo craniotomy for glioma resection, randomly divided into three groups:S1, S2 and S3(n=20). Inductions [...]
Objective:To study the expression of Cyclin B1 in human gliomas and its relationship with cellular proliferation activity.Methods:Samples used in this study were from consented patients admit-ed to our hospital between 2001 and 2004. The histopathological diagnosis and grade of the 62 tumor were confirmed by two pathologists separately and were retrospectively reviewed, according to the [...]
Objective Pi3k is the key signaling molecule in life activities, in many tumors it is abnormal and considered the primary pathway of the cell survival. Not only can it promote the tumor cell proliferation ,but also inhibit apoptosis of tumor cells.In this study,w e find the effection and mechanism of the selective interruption on the [...]
Objective:Comparative analysis of glioma in MR susceptibility-weighted imaging(SWI) for clinical diagnostic imaging performance characteristics。To investigate the feasibility of SWI in grading of glioma..Methods:36 cases of glioma identity by pathological diagnosis, using Siemens 3.0T MR routine sequence scanning (including T1WI, T2WI, T2-FLAIR and T1 enhancement) and SWI sequence scanning, image of high qualification by two doctors [...]
Background:The annual incidence of primary brain tumors was 10/10 million people, intracranial tumors occupy aboutl.8% of the tumor in the body, accounted for 2.35% of death caused by malignant tumors, in the tenth place.While about 60% of primary intracranial tumors are glial cell tumors. The main treatment of glioma is surgery, combin-d with comprehensive treatment [...]
Objectives and Backgroud:To investigate the inhibition and mechanism of Temozolomide(TMZ) and PTX are very effective drug for malignant gliomas with significant survival increase.Preclinic and clinic investingations have demonstrated that the combination therapy of TMZ with PTX on glioma in vitro are empty. Our findings not only suggest the original TMT Paclitaxel in combination with great [...]
Objective: The glioma nude mice animal models are set as a research platform. Through the tail vein injecting microbubble ultrasound contrast agent in the nude mice and irradiated by high intensity focused ultrasound (HIFU) on tumor tissue, that is uesd to study the changes of proliferating cell nuclear antigen in glioma cells and their apoptosis [...]
Objective: Malignant gliomas so far still remain incurable brain tumors because of their diffuse-invasive growth. AXL gene plays an important role in the growth, differentiation, invasion and metastasis of gliomas. This study is to explore the expression and significance of AXL gene in normal brain, malignant gliomas and meningiomas.and to provide foundation of laboratory for [...]
Human glioma was the most frequent human brain tumor and one year survival rate of most high-grade glioma was 46%. The oncogenesis of glioma and effective therapy method was the most core theme of neurosurgery and euro-oncology. Recently, some tumor oncogenesis correlated molecular events, including EGFR over expression, PTEN and p53 gene mutant, were discovered [...]
BACKGROUND:Gliomas are the most common brain malignancy tumor.HIF-1α,which helps sustain the homeostasis of oxygen in the development of malignant tumors and metastasis,is considered to play a key role in the adaption of tumor cells to hypoxia.It is conceivedthat HIF-1αmay play a key role in the angiogenesis of gliomas.But there is not any report about the [...]
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