Prostate cancer (prostate cancer, PCa) is the most common malignant cancer in Europe and America countries, and is the second leading cause of death to lung cancer in men. Although its incidence in China is lower than Europe countries, prostate cancer has become more important cause of death in the old men as the average [...]
Objective Gliomas are the most common type of intracranial tumors, which account for about 50% of all the primary brain tumors.Because of their infiltrating and scalable growth,the tumor tissues often have no clear border with surrounding normal brain tissues.So surgery is hard to eradicate the tumor.What’s more,the glioma cells are not sensitive to traditional radiotherapy [...]
BackgroundCoronary heart disease (CHD) is a leading cause of death and burden of disease in China and most other countries, which can do great harm to human health and quality of life. Also, the incidence and mortality rate of CHD in China have been going up in recent years.CHD is a multi-factorial disease related to [...]
Objective:To study the functions and correlations during the development and progress of primary epithelial ovarian cancer by detecting the expressions of PI3K and AKT of PI3K/AKT signaling pathway genes, Survivin and XIAP of Inhibitor of apoptosis proteins (IAPs) members,and Cyt-c,Caspase-9,Bax and Bcl-2 of regulation of the mitochondrial apoptosis pathway-related factors in normal epithelial ovarian tissues, [...]
Objective:To compare the different gene expressional changes and difference in gene ontology and pathway between RST and dCST after transection at 24h; try to explain different regeneration abilities of different evolved spinal cord tracts using evolutionism at the gene level; and provide a robust framework in the treatment of SCI in the light of evolutionism.Methods:Gene [...]
Background and objects:CHFR(checkpoint with FHA and ring finger) is a new cell cycle checkpoint gene,which is inactivated in human cancers. During stress mitosis,it has the function of delaying chromatin condensation and progression to the mitotic phase.Some research results show that, in many tumors,CHFR expression silencing because of the CpG island methylation. In tumor cells CHFR [...]
Objective The OXA-type extended-spectrumβ-lactamases(ESBLs) are originated from OXA-10,OXA-2 and OXA-1. They are divided into five groups, Group I and Group II are the major groups. Most of them are produced by Pseudomonas aerugenosa. We have studied the research in order to acquire the prevalence and genotype distribution of OXA-type ESBLs in Pseudomonas aerugenosa strains which [...]
Objections To study the related individual acquired factors,which would result in the different antihypertension efficacy of metoprolol inβ1-adrenergic receptor(β1-AR)gene – directed therapy.In addition,to investigate the role of DNA methylation in the control of expression ofβ1-AR gene,this may be the epigenetic molecular mechanism of different antihypertension efficacy of metoprolol.Our goal was to enrich and increase the [...]
Objective: To investigat the association between polymorphisms of the norepinephrine transporter gene(solute carrier family 6, member 2; SLC6A2 promoter 3 ) angiotensin converting enzyme(ACE) gene insertion/deletion and essential hypertension complicated by heart failure.Methods: We collected EH-HF group of 176 subjects with NYHAⅢ-Ⅳfunctional class, and matched EH group with normal functional class and control subjects controlling [...]
Objective: To investigate the association between polymorphisms of the -1023 region ofβ2-adrenoceptor(β2-AR/-1023) gene-G/A,angiotensin converting enzyme (ACE) gene insertion/deletion(I/D) and essential hypertension(EH) complicated by ischemic cerebrovascular disease(ICVD).Methods: We collected 345 subjects of EH-ICVD group, 315 subjects of EH without ICVD(EH-non-ICVD) group and 255 subjects of control group.β2-AR/-1023 gene-G/A were determined with the use of Polymerase Chain [...]
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