Objective:To investigate the effects of ligustrazine on expression of FoXO3a、MAFbx and MuRF1in denervated skeletal muscle atrophy rats.Methods:54female Wistar rats were randomly divided into3groups, which included normal control group (A n=6), denervated control group (B n=24), ligustrazine intervention group (C n=24).The denervated control groups and ligustrazine intervention groups were subjected to establishment of denervated gastrocnemius models.Normal [...]
Objective: Chronic hepatitis B is one of infective diseases to threaten human health which is mainly caused by continuing exist of hepatitis B virus. Hepatitis B virus damages hepatocytes by activating immune system. Repeating inflammations in the liver will lead to hepatic cirrhosis, even hepatic carcinoma if virus cannot be completely cleared.The mechanism resulted in [...]
Objective: Cerebral ischemia is the first leading cause of death and the most frequent cause of permanent disability in adults. The pathological mechanism for ischemic injury was a perplexing cascade reaction, including inflammation, oxidative stress and perturbation of calcium homeostasis, cytotoxic effect and reactive oxygen species/reactive nitrogen species (ROS/RNS). It is generally believed that excessive [...]
ObjectiveGlucocorticoids are the first-line chemotherapy drugs in many blood malignancies and their resistance is the main reason resulting in refractory and relapse. Currently the study about the mechanism of glucocorticoid resistance is a clinically urgent mission. FoxO3a, a key member of the FOXO family, plays a role in cell signaling pathway include the regulation of [...]
PurposeTo alleviate mouse allergic airway inflammatory diseases by administration of IL-2(IL-2) combined with dexamethasone.To explore the role of FoxO3a in glucocorticoid-induced apoptosis by silencing foxo3a siRNA gene and detection of lymphocyte apoptosis after dexamethasone treatment.To explore the mechanism of the expansion of regulatory T cells by IL-2 combined with dexamethasone pre-treatment.Methodsa) To establish a mouse [...]
Objective:To study the protective effects of Tempol against UVB irradiation-induced damage on cultured HaCaT cells.Methods:HaCaT cells were irradiated with UVB for 4 second followed by 24 hours of incubation with fresh medium.Cell proliferation ability was studied with MTT asssy and early apoptosis was analyzed by flow cytometric method.Gene expressions of FoxO3a and BubR1 were detected [...]
Objective: To study the effects of resveratrol on ovarian follicle development and the mechanism of neonatal oocyte apoptosis in rats.Methods: Ovarian development of neonatal rats which were treated with resveratrol (20mg/kg/d) by intraperitoneal injection on day 1-4, or whose mothers were treated with resveratrol (20mg/kg/d) on day 10.5 after detected vaginal plug till delivery by [...]
SIRT1 protein expression and gene status in DLBCL and its effects on biologic behaviour of DLBCL cell linesBackground:Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy of mature B lymphocytes accounted for 30%-40% ofNon-Hodgkin lymphoma. DLBCL is a heterogeneous tumor, clinically, morphologically and genetically. The molecular mechanisms are largely unknown and need to be further [...]
Background and objectiveCalorie Restriction （CR） is one of the most effective methods to increase longevity,delay ageing and improve health. CR retards age-related neurondegeneration, which ischaracterized by decline in learning and memory ability. Majority of former data wereobtained from life-long CR rats or mice. Whereas there are numerous reports aboutage-related diseases prevention by CR, the effects [...]
Objective:Signaling through the phosphatidylinositol 3-kinase(PI3K)-Akt pathway is crucial for metabolic responses to insulin,and defects in PI3K-Akt signaling have been demonstrated in insulin resistance.PTEN(phosphatase and tensin homologue deleted on chromosome 10),firstly named after tumor suppressor,is a potent negative regulator of the PI3K-Akt pathway.FoxO family are transcription factors and belong to downstream molecules and then can be [...]
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